Professor Mark Good - BSc London, DPhil York

Professor

Research group:
Neuroscience
Email:
Good@cardiff.ac.uk
Telephone:
029 208 75867
Location:
Tower Building, Park Place

Research summary

The medial temporal lobe and particularly the hippocampus has long been associated with memory function in humans and non-human animals. This region is often involved in psychiatric and neurodegenerative conditions, such as schizophrenia and Alzheimer’s disease. My current research is aimed at addressing two main questions: 1) What role does the hippocampus and associated brain structures play in memory? and 2) How do neurodegenerative conditions influence the function of the hippocampus? In addressing these questions I use preclinical models of  brain pathology synaptic including genetic models of heritable neurodegenerative conditions, such as Alzheimer’s disease and frontotemporal dementia. Current projects include: assessment of the psychological and neural substrates of configural and episodic-like memory, characterisation of transgenic models of Alzheimer’s disease; investigation of the psychological and neural benefits of dietary supplements on Alzheimer’s pathology; assessment of a novel antibody treatment for amyloid pathology; investigation of cannabinoid receptors in memory and neurodegenerative diseases; the role of maternal priming in the onset of Alzheimer’s disease in later life.

Teaching summary

My teaching includes: lectures on biological psychology to level 2 undergraduate students; a complete level 3 module on the neuroscience of learning and memory; lectures to neuroscience students and medical students on preclinical models of Alzheimer’s disease and higher cortical function in humans, respectively.

Selected publications (2014 onwards)

 

Full list of publications

 

Funding

BBSRC: Attention and predictive learning (John Pearce)  £574,671, 2010-2013

KTP: Improved lipid containing neutraceuticals (John Harwood) £208,748, 2009-2011

Alzheimer’s Society Studentship: Evaluation of a novel antibody therapy for AD (Emma Kidd) £75,000, 2009-1011

Alzheimer’s Research Trust: Molecular basis for beneficial effects of omega-3 fatty acids (John Harwood £296,000, 2007-2011

NIH service contract: with Prof Steve Goldberg:  Cannabinoid receptor modulation of GABA activity in APP mice $20,000 pa, 2010-11

Research group

Behavioural Neuroscience

Research collaborators

Professor Robert Honey (Cardiff University)

Professor John Harwood (Cardiff University)

Professor John Pearce (Cardiff University)

Dr. Emma Kidd (Cardiff University)

Dr. David Bannerman (Oxford University)

Dr. Robert Williams (University of Bath)

Postgraduate research interests

Postgraduate students currently carry out research directed at investigating the neural substrates of animal cognition and or evaluating putative therapies for amyloid pathology (see below)

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application here.

Current students

John Anderson –  (writing up) The role of insulin resistance in the development of amyloid pathology. BBSRC/GSK CASE award

Katie Hall (current) The infuence of dietary supplements on memory and amyloid pathology in mouse models of Alzheimer’s Disease

Martha Hvoslefeide – (current) The effect of steric hindrance of Ab processing on cognition in APP mice

Laura Middleton (current) Maternal priming & Alzheimer’s Disease:The influence of diet and exercise on amyloid pathology in a mouse model of Alzheimer’s Disease

Caroline O’Hagan (current) The influence of probiotics on emotion and executive function in rodents

Alice Palmer (current) Amyloid pathology and hippocampal synaptic plasticity in mouse models of Alzheimer’s Disease

Previous students

Phil Barnes – (submitted)Characterisation of a transgenic mouse model of Alzheimer’s disease. MRC

Cecile Bascoul – (submitted) Inflammatory processes in Alzheimer’s Disease: Investigation of  dietary doxosahexanoec acid supplements in a mouse transgenic model. Department funded.

Dean Burnett – (submitted) Episodic-like memory in rats. BBSRC

James Dachtler- (submitted) GluR-1 roles in learning and synaptic plasticity

Mark Day – (submitted) The role of oestrogen in cognition. GSK

Gemma Hale – (submitting) Memory processes in a mouse transgenic model of Alzheimer’s disease. MRC

Andrew Hayward – (submitted) Cue competition in spatial learning. BBSRC

Alex Johnson – (submitted) The role of GluR1A receptors in learning and memory. Department funded

Peter Jones – (submitted) The role of the hippocampus in processing the geometry of the environment. Department funded

Mariah Lelos – (submitted) Frontal-amygdala interactions in an APP model of Alzheimer’s disease. MRC

Jo Oswald – (submitted) An analysis of entorhinal cortex function in the rat. MRC

Pippa Pugh – (submitted) Models of inflammation in Alzheimer’s disease. GlaxoSmithKline

Amy Reichelt – (submitted) Neurobiology of response conflict resolution- BBSRC/Eli Lilly

Kristina Wilton – (submitted) The effects of protein phosphorylation inhibition on tau production and cognition in rats. MRC

Undergraduate education

BSc. Psychology (2.1) University of London

Postgraduate education

DPhil. Behavioural Neuroscience University of York

Employment

1990-1994. University of Edinburgh. Post-doc. associate.

1994-to present. Lecturer, Reader and Personal Chair Cardiff University