My research investigates the neural basis of learning and memory through the examination of different rodent models of cognitive impairment. Trisomy of chromosome 21 is known to cause Down’s syndrome, a genetic condition characterized by intellectual disabilities. Located on chromosome 21 is also the gene encoding the amyloid precursor protein (APP), which is crucial in Alzheimer’s disease, a neurodegenerative disorder mainly characterized by memory impairments. Individuals with Down’s syndrome show in fact increased risk of developing Alzheimer’s disease. Hence, genes on chromosome 21 play a fundamental role in learning and memory. Genetically modified mouse models triplicating different selected genes of chromosome 21 have been developed and I will characterise the behavioural phenotypes of such mouse strains (Dp1Tyb, Ts2yey, Ts3yey). By comparing their cognitive deficits and by assessing as well as manipulating brain activity, I aim to relate specific genes to the functioning of specific brain regions and eventually to specific roles in learning and memory.
2015–present: Practical Tutor for 1st year undergraduates – Leading tutorials and marking practical reports in order to develop student’s scientific report-writing skills as well as knowledge of statistical methods.
Full list of publications
Research topics and related papers
- Learning and Memory in mouse models of cognitive impairments (Down’s syndrome, Alzheimer’s disease)
- Chromosome 21, Amyloid precursor protein (APP)
School of Psychology, Cardiff University (2015-2018)
Neuroscience, Behavioural neuroscience
2008 – 2012: BSc Psychology, University of Zurich (Switzerland)
Minor in Media and Communication Science (BA)
Postgraduate education2012 – 2015: MSc Cognitive Neuroscience, University of Zurich (Switzerland) - final grade 5.8/6
Minor in Neuroinformatics (BSc and MSc)
02/2015 – 06/2015: Research assistant, Clinical Neurorehabilitation Laboratory, University of Zurich and ETH Zurich
03/2014 – 09/2014: Research internship, Department of Neurology, University Hospital Zurich
07/2013 – 09/2013: Research internship, Virtual Neurorehabilitation Laboratory, University of Zurich and ETH Zurich