Adam Brelsford

Research group:
Neuroscience
Email:
BrelsfordAR1@cardiff.ac.uk
Telephone:
029 208 70141
Location:
Tower Building, Park Place

Research summary

Alzheimer’s disease (AD) is a progressive neurodegenerative condition, featuring symptoms of dementia such as memory loss, impaired communication and diminished visuospatial skills, and is pathologically characterised by toxic amyloid-β (Aβ) plaques and hyperphosphorylated tau ‘tangles’ in the brain. Depression too can arise in AD, and the two conditions appear to inter-relate in a manner which is poorly understood.
My research will probe the link between amyloid processing and depression in two murine models of AD. As well as establishing whether disrupting amyloid processing has an impact on cognitive and hedonic state in these models, the work may also encompass using antidepressants or other pharmacological agents to gauge their utility in addressing both depressive- and dementia-like phenomena.

Teaching summary

Laboratory demonstrating in Pharmacy.

Full list of publications

 

Research topics and related papers

Alzheimer’s disease (AD) is a progressive neurodegenerative condition, featuring symptoms of dementia such as memory loss, impaired communication and diminished visuospatial skills, and is pathologically characterised by toxic amyloid-β (Aβ) plaques and hyperphosphorylated tau ‘tangles’ in the brain. Depression too can arise in AD, and the two conditions appear to inter-relate in a manner which is poorly understood.
My research will probe the link between amyloid processing and depression in two murine models of AD. As well as establishing whether disrupting amyloid processing has an impact on cognitive and hedonic state in these models, the work may also encompass using antidepressants or other pharmacological agents to gauge their utility in addressing both depressive- and dementia-like phenomena.

Funding

School of Psychology

School of Pharmacy

Research group

Neuroscience, Behavioural Neuroscience

Research collaborators

Professor Mark Good
Dr Dominic Dwyer
Dr Emma Kidd
Dr Rhian Thomas

Undergraduate education

2010 – 2014 Master of Pharmacy (1st Class Honours), Cardiff School of Pharmacy and Pharmaceutical Sciences.

Employment

July 2014 – July 2015 Hospital pre-registration pharmacist
September 2015 onwards – Registered pharmacist