School of Psychology Contacts & people

Dr David McGonigle

Lecturer

Research groups:
Neuroscience
Cognitive science
Email:
McGonigleD@cardiff.ac.uk
Telephone:
+44(0)29 2087 0353
Location:
Tower Building, Park Place

Research summary

Studying sensory processing means focusing on the rules and mechanisms that the brain uses to make sense of the world. I use the somatosensory system – the sense of touch – as a gateway to uncover some of the fundamental principles that govern neuronal communication in the human brain. I am particularly interested in the dynamic, plastic nature of sensory processing: how our perceptions are critically dependent on the waxing and waning of millisecond to millisecond changes in brain activity.

Using functional neuroimaging (fMRI, MEG and EEG) and behavioural techniques I focus on three main areas:

i) Where, when and how are tactile stimuli processed in the human brain?

ii) The principles underlying short-term changes in perception (adaptation) and longer-term changes (learning).

iii) How alterations in sensory processing contribute to brain conditions, such as Autism Spectrum Disorder (ASD).

I have also recently become interested in using brain stimulation to explore these questions, using a novel technique called trans-Cranial Direct Stimulation (tDCS). Finally, I have an active interest in the methods and reliability of non-invasive neuroimaging.

Teaching summary

Level 1 Psychology: PS1107 ‘Introduction to cognitive and biological psychology’ FSM

Level 3 Psychology PS3209 ‘Structural and functional neuroimaging’

MSc ‘Neuroimaging Methods and Applications’

Selected publications (2008 onwards)

2014

Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. (2014). Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABANeuroImage, 86, 43-52. (10.1016/j.neuroimage.2012.12.004)

2013

Evans, C. J., Puts, N., Robson, S. E., Boy, F., McGonigle, D., Sumner, P., Singh, K. D. and Edden, R. A. E. (2013). Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editingJournal of Magnetic Resonance Imaging, 38(4), 970-975. (10.1002/jmri.23923)

2012

McGonigle, D. (2012). Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variabilityNeuroImage, 62(2), 1116-1120. (10.1016/j.neuroimage.2012.01.023)

2011

Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. (2011). Regionally specific human GABA concentration correlates with tactile discrimination thresholdsJournal of Neuroscience, 31(46), 16556-16560. (10.1523/JNEUROSCI.4489-11.2011) pdf

Wiestler, T., McGonigle, D. and Diedrichsen, J. (2011). Integration of sensory and motor representations of single fingers in the human cerebellumJournal of Neurophysiology, 105(6), 3042-3053. (10.1152/jn.00106.2011)

2010

Evans, C. J., McGonigle, D. and Edden, R. A. E. (2010). Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortexJournal of Magnetic Resonance Imaging, 31(1), 204-209. (10.1002/jmri.21996)

Gountouna, V. E., Job, D. E., McIntosh, A., Moorhead, T. W. J., Lymer, G. L., Whalley, H. C., Hall, J., G.D., W., Brennan, D., McGonigle, D., Ahearn, T., Cavanagh, J., Condon, B., Hadley, D., Marshall, I., Murray, A., Steele, J., Wardlaw, J. and Lawrie, S. (2010). Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping taskNeuroImage, 49(1), 552-560. (10.1016/j.neuroimage.2009.07.026)

Gradin, V., Gountouna, V., Waiter, G., Ahearn, T., Brennan, D., Condon, B., Marshall, I., McGonigle, D., Murray, A., Whalley, H., Cavanagh, J., Hadley, D., Lymer, K., McIntosh, A., Moorhead, T. W., Job, D., Wardlaw, J., Lawrie, S. and Steele, J. D. (2010). Between- and within-scanner variability in the CaliBrain study n-back cognitive taskPsychiatry Research: Neuroimaging, 184(2), 86-95. (10.1016/j.pscychresns.2010.08.010)

Hall, J., Whalley, H. C., McKirdy, J. W., Sprengelmeyer, R., Santos, I. M., Donaldson, D. I., McGonigle, D., Young, A. W., McIntosh, A. M., Johnstone, E. C. and Lawrie, S. M. (2010). A common neural system mediating two different forms of social judgementPsychological Medicine, 40(7), 1183-1192. (10.1017/S0033291709991395) pdf

Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. (2010). Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'Neuropsychologia, 48(1), 145-155. (10.1016/j.neuropsychologia.2009.08.024)

2008

Erchova, I. and McGonigle, D. (2008). Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological dataChaos, 18(1) (10.1063/1.2900015)

Hall, J., Whalley, H. C., McKirdy, J. W., Romaniuk, L., McGonigle, D., McIntosh, A. M., Baig, B. J., Gountouna, V., Job, D. E., Donaldson, D. I., Sprengelmeyer, R., Young, A. W., Johnstone, E. C. and Lawrie, S. M. (2008). Overactivation of fear systems to neutral faces in schizophreniaBiological Psychiatry, 64(1), 70-73. (10.1016/j.biopsych.2007.12.014)

Online publications

Full list of publications

2014

Mullins, P. G., McGonigle, D., O'Gorman, R. L., Puts, N., Vidyasagar, R., Evans, C. J. and Edden, R. A. E. (2014). Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABANeuroImage, 86, 43-52. (10.1016/j.neuroimage.2012.12.004)

2013

Evans, C. J., Puts, N., Robson, S. E., Boy, F., McGonigle, D., Sumner, P., Singh, K. D. and Edden, R. A. E. (2013). Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editingJournal of Magnetic Resonance Imaging, 38(4), 970-975. (10.1002/jmri.23923)

2012

McGonigle, D. (2012). Test-retest reliability in fMRI: Or how I learned to stop worrying and love the variabilityNeuroImage, 62(2), 1116-1120. (10.1016/j.neuroimage.2012.01.023)

2011

Puts, N., Edden, R. A. E., Evans, C. J., McGlone, F. and McGonigle, D. (2011). Regionally specific human GABA concentration correlates with tactile discrimination thresholdsJournal of Neuroscience, 31(46), 16556-16560. (10.1523/JNEUROSCI.4489-11.2011) pdf

Wiestler, T., McGonigle, D. and Diedrichsen, J. (2011). Integration of sensory and motor representations of single fingers in the human cerebellumJournal of Neurophysiology, 105(6), 3042-3053. (10.1152/jn.00106.2011)

2010

Evans, C. J., McGonigle, D. and Edden, R. A. E. (2010). Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortexJournal of Magnetic Resonance Imaging, 31(1), 204-209. (10.1002/jmri.21996)

Gountouna, V. E., Job, D. E., McIntosh, A., Moorhead, T. W. J., Lymer, G. L., Whalley, H. C., Hall, J., G.D., W., Brennan, D., McGonigle, D., Ahearn, T., Cavanagh, J., Condon, B., Hadley, D., Marshall, I., Murray, A., Steele, J., Wardlaw, J. and Lawrie, S. (2010). Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping taskNeuroImage, 49(1), 552-560. (10.1016/j.neuroimage.2009.07.026)

Gradin, V., Gountouna, V., Waiter, G., Ahearn, T., Brennan, D., Condon, B., Marshall, I., McGonigle, D., Murray, A., Whalley, H., Cavanagh, J., Hadley, D., Lymer, K., McIntosh, A., Moorhead, T. W., Job, D., Wardlaw, J., Lawrie, S. and Steele, J. D. (2010). Between- and within-scanner variability in the CaliBrain study n-back cognitive taskPsychiatry Research: Neuroimaging, 184(2), 86-95. (10.1016/j.pscychresns.2010.08.010)

Hall, J., Whalley, H. C., McKirdy, J. W., Sprengelmeyer, R., Santos, I. M., Donaldson, D. I., McGonigle, D., Young, A. W., McIntosh, A. M., Johnstone, E. C. and Lawrie, S. M. (2010). A common neural system mediating two different forms of social judgementPsychological Medicine, 40(7), 1183-1192. (10.1017/S0033291709991395) pdf

Zeman, A., Della Sala, S., Torrnes, L., Gountouna, V. E., McGonigle, D. and Logie, R. (2010). Loss of imagery phenomenology with intact visuo-spatial task performance: a case of 'blind imagination'Neuropsychologia, 48(1), 145-155. (10.1016/j.neuropsychologia.2009.08.024)

2008

Erchova, I. and McGonigle, D. (2008). Rhythms of the brain: An examination of mixed mode oscillation approaches to the analysis of neurophysiological dataChaos, 18(1) (10.1063/1.2900015)

Hall, J., Whalley, H. C., McKirdy, J. W., Romaniuk, L., McGonigle, D., McIntosh, A. M., Baig, B. J., Gountouna, V., Job, D. E., Donaldson, D. I., Sprengelmeyer, R., Young, A. W., Johnstone, E. C. and Lawrie, S. M. (2008). Overactivation of fear systems to neutral faces in schizophreniaBiological Psychiatry, 64(1), 70-73. (10.1016/j.biopsych.2007.12.014)

2007

Ladabaum, U., Roberts, T. P. and McGonigle, D. (2007). Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging studyNeuroimage, 34(2), 724-732. (10.1016/j.neuroimage.2006.07.033)

Zhu, Z., Disbrow, E. A., Zumer, J. M., McGonigle, D. and Nagarajan, S. S. (2007). Spatiotemporal integration of tactile information in human somatosensory cortexBMC Neuroscience, 8(1) (10.1186/1471-2202-8-21) pdf

2005

Shehab, S., McGonigle, D., Hughes, D. I., Todd, A. J. and Redgrave, P. (2005). Anatomical evidence for an anticonvulsant relay in the rat ventromedial medullaEuropean Journal of Neuroscience, 22(6), 1431-1444. (10.1111/j.1460-9568.2005.04326.x)

Smith, S. M., Beckmann, C. F., Ramnani, N., Woolrich, M. W., Bannister, P. R., Jenkinson, M., Matthews, P. M. and McGonigle, D. (2005). Variability in fMRI: A re-examination of intersession DifferencesHuman Brain Mapping, 24(3), 248-257. (10.1002/hbm.20080)

2004

Matharu, M. S., Cohen, A. S., McGonigle, D., Ward, N., Frackowiak, R. S. and Goadsby, P. J. (2004). Posterior Hypothalamic and Brainstem Activation in Hemicrania ContinuaHeadache: The Journal of Head and Face Pain, 44(8), 747-761. (10.1111/j.1526-4610.2004.04141.x)

2003

Ladabaum, U., Roberts, T. P. and McGonigle, D. (2003). Gastric fundic distension activates fronto-limbic structures but not somatosensory cortex: A functional MRI (fMRI) study [Abstract]Gastroenterology, 124(4 (S1)), A253. (10.1016/S0016-5085(03)81268-4)

2002

McGonigle, D., Hanninen, R., Hari, R. and Salenius, S. (2002). Whose arm is it anyway? An fMRI case study od supernumerary phantom limbBrain, 125(6), 1265-1274. (10.1093/brain/awf139)

2000

McGonigle, D., Howseman, A. M., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J. and Holmes, A. P. (2000). Variability in fMRI: an examination of intersession differencesNeuroImage, 11(6), 708-734. (10.1006/nimg.2000.0562)

1999

May, A., Ashburner, J., Buchel, C., McGonigle, D., Friston, K. J., Frackowiak, R. S. J. and Goadsby, P. J. (1999). Correlation between structural and functional changes in brain in an idiopathic headache syndromeNature Medicine, 5(7), 836-838. (10.1038/10561)

1996

McGonigle, D., Maxwell, D. J., Shehab, S. A. S. and Kerr, R. (1996). Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the ratBrain Research, 742(1-2), 1-9. (10.1016/S0006-8993(96)00942-0)

Funding

Autism Speaks

Susanne and Bob Wright Trailblazer Award

(2012-2013; Costs $100,000)

NIHR Fellowship
A Pilot Neuroimaging Study of Chronic Regional Pain Syndrome (CRPS)
(2010-2015; Costs £154,345)

The Waterloo Foundation
Advanced Neuroimagingin BECTS
(2010-2012; Costs £113,039)

The Waterloo Foundation
Autistic Spectrum Disorder (ASD) and the neurobiology of sensory symptoms
(19/04/10 - 18/04/12; Costs £53, 473)

TheWaterlooFoundation
Travel Grant to Attend IMFAR 2010
(2010; Costs £1550)

Royal Society Research Grant
An Investigation of the Spatiotemporal Integration of Tactile Information in Somatosensory Cortex using Magnetoencephalography (MEG)
(01/04/08-31/03/09; Costs £14,898)