School of Psychology Contacts & people

Professor David Linden

Professor

Research group:
Neuroscience
Email:
LindenD@cardiff.ac.uk
Telephone:
+44(0)29 2087 6785
Location:
Tower Building, Park Place

Research summary

1) Biomarkers for mental disorders
Mental disorders are defined at the level of phenotypes/ clinical presentation but relatively little is known about the underlying biological mechanisms. At the same time, there is a huge interest in biomarkers of mental disorders such as schizophrenia to improve diagnosis and treatment monitoring. We aim to identify such biomarkers by combining the tools of cognitive neuroscience (behavioural paradigms, functional imaging, non-invasive electrophysiology) with molecular genetics, for example using the genetic variants identified in genome-wide association studies. This research programme is embedded in the activities of the University’s Neuroscience and Mental Health Research Institute (NMHRI). We also collaborate with the Schizophrenia Research Groups at the Dept. of Psychiatry, Frankfurt University Medical School and at Erasmus Medical College, Rotterdam.

2) Neurobiology of cognition/emotion interactions
Our cognitive performance is greatly influenced by the emotional salience of the processed material and our motivational states. We investigate such emotion-cognition interactions in the domain of visual working memory, focusing on threat-cues such as angry faces. We combine behavioural and imaging techniques with molecular genetics, pharmacology and patient studies (e.g. in Parkinson’s disease). This research is funded by a BBSRC grant in conjunction with Bangor University (Prof Jane Raymond, Dr John Hindle, Dr Margaret Jackson).

3) Social cognitive neuroscience
Humans are prototypically social animals. One aspect of our social fabric is that we constantly compare ourselves with other conspecifics. We investigate the neural mechanisms and consequences of such comparisons on judgements and decision making with behavioural, imaging and genetic methods. This research is funded by a bilateral ESRC/DFG grant in conjunction with Cologne University (Prof Thomas Mussweiler, Dr Gayannee Kedia). Local collaborator is Dr Niklas Ihssen. We also collaborate with the Social Cognition and Affective Neuroscience group at the Dept. of Psychiatry of the Charite Medical School, Berlin (Dr Ullrich Wagner, Prof Henrik Walter).

4) Clinical applications of functional imaging
We develop protocols for the clinical application of real-time fMRI. Through this method patients can be trained in the self-regulation of brain networks, which may help overcome dysfunctional or impaired physiological processes. We are piloting this technique in affective disorders, movement disorders and addiction. This work is partly funded by a NIHSCR PhD studentship to Isabelle Habes. We collaborate with Maastricht University (Prof Rainer Goebel, Dr Bettina Sorger) and Bangor University (Prof Miles Cox).

Other research helps to understand how social values get translated into action. This research is being undertaken in collaboration with colleagues in the Values in Action (ViA) Centre, at Cardiff University.

Teaching summary

Biological Psychiatry
Clinical applications of functional imaging

Selected publications (2008 onwards)

2014

Ihssen, N., Linden, D. E. J., Miller, C. E. and Shapiro, K. L. (2014). Neural mechanisms underlying visual short-term memory gain for temporally distinct objectsCerebral Cortex (10.1093/cercor/bhu021)

2013

Habes, I., Krall, S. C., Johnston, S. J., Yuen, K. S. L., Healy, D., Goebel, R., Sorger, B. and Linden, D. E. J. (2013). Pattern classification of valence in depressionNeuroImage: Clinical, 2, 675-683. (10.1016/j.nicl.2013.05.001) pdf

Kedia, G., Lindner, M., Mussweiler, T., Ihssen, N. and Linden, D. E. J. (2013). Brain networks of social comparisonNeuroReport, 24(5), 259-264. (10.1097/WNR.0b013e32835f2069)

Keedwell, P. A. and Linden, D. E. J. (2013). Integrative neuroimaging in mood disordersCurrent Opinion in Psychiatry, 26(1), 27-32. (10.1097/YCO.0b013e32835a0b63)

Morgan, H. M., Jackson, M. C., van Koningsbruggen, M. G., Shapiro, K. L. and Linden, D. E. J. (2013). Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctionsBrain Stimulation, 6(2), 122-129. (10.1016/j.brs.2012.03.001)

Oertel-Knochel, V., Knochel, C., Rotarska-Jagiela, A., Reinke, B., Prvulovic, D., Haenschel, C., Hampel, H. and Linden, D. E. J. (2013). Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrumCerebral Cortex, 23(1), 61-70. (10.1093/cercor/bhr380)

2012

Healy, D. T., Le Noury, J., Linden, S. C., Harris, M., Whitaker, C., Linden, D. E. J., Baker, D. and Roberts, A. P. (2012). The incidence of admissions for schizophrenia and related psychoses in two cohorts: 1875-1924 and 1994-2010British Medical Journal Open, 2(1) (10.1136/bmjopen-2011-000447) pdf

Jackson, M. C., Linden, D. E. J. and Raymond, J. E. (2012). “Distracters” do not always distract: visual working memory for angry faces is enhanced by incidental emotional wordsFrontiers in Psychology, 3 (10.3389/fpsyg.2012.00437) pdf

Johnston, S. J., Linden, D. E. J. and Shapiro, K. L. (2012). Functional imaging reveals working memory and attention interact to produce the attentional blinkJournal of Cognitive Neuroscience, 24(1), 28-38. (10.1162/jocn_a_00054) pdf

Knöchel, C., O'Dwyer, L., Alves, G., Reinke, B., Magerkurth, J., Rotarska-Jagiela, A., Prvulovic, D., Hampel, H., Linden, D. E. J. and Oertel-Knöchel, V. (2012). Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relativesSchizophrenia Research, 140(1-3), 129-135. (10.1016/j.schres.2012.06.001)

Knöchel, C., Oertel-Knöchel, V., Schönmeyer, R., Rotarska-Jagiela, A., van de Ven, V., Prvulovic, D., Haenschel, C., Uhlhaas, P., Pantel, J., Hampel, H. and Linden, D. E. J. (2012). Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relativesNeuroImage, 59(2), 926-934. (10.1016/j.neuroimage.2011.07.088)

Lancaster, T. M., Linden, D. E. J. and Heerey, E. A. (2012). COMT val158met predicts reward responsiveness in humansGenes, Brain and Behavior, 11(8), 986-992. (10.1111/j.1601-183X.2012.00838.x)

Linden, D. E. J., Oosterhof, N. N., Klein, C. and Downing, P. E. (2012). Mapping brain activation and information during category-specific visual working memoryJournal of Neurophysiology, 107(2), 628-639. (10.1152/jn.00105.2011)

Linden, D. E. J., Habes, I., Johnston, S. J., Linden, S., Tatineni, R., Subramanian, L., Sorger, B., Healy, D. T. and Goebel, R. (2012). Real-time self-regulation of emotion networks in patients with depressionPLoS ONE, 7(6) (10.1371/journal.pone.0038115) pdf

Linden, D. E. J. (2012). The biology of psychological disorders. Basingstoke: Palgrave Macmillan.

Linden, D. E. J. (2012). The challenges and promise of neuroimaging in psychiatryNeuron, 73(1), 8-22. (10.1016/j.neuron.2011.12.014)

Oertel-Knöchel, V., Knöchel, C., Matura, S., Rotarska-Jagiela, A., Magerkurth, J., Prvulovic, D., Haenschel, C., Hampel, H. and Linden, D. E. J. (2012). Cortical-basal ganglia imbalance in schizophrenia patients and unaffected first-degree relativesSchizophrenia Research, 138(2-3), 120-127. (10.1016/j.schres.2012.02.029)

Oertel-Knöchel, V., Reinke, B., Hornung, A., Knöchel, C., Matura, S., Knopf, M., Prvulovic, D., O'Dwyer, L., Lindner, M., Rau, A., Hampel, H., Haenschel, C. and Linden, D. E. J. (2012). Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methodsJournal of Nervous and Mental Disease, 200(4), 296-304. (10.1097/NMD.0b013e31824ceef7)

Sreenivas, S., Boehm, S. G. and Linden, D. E. J. (2012). Emotional faces and the default mode networkNeuroscience Letters, 506(2), 229-234. (10.1016/j.neulet.2011.11.012)

Wolf, C. and Linden, D. E. J. (2012). Biological pathways to adaptability - interactions between genome, epigenome, nervous system and environment for adaptive behaviorGenes, Brain and Behavior, 11(1), 3-28. (10.1111/j.1601-183X.2011.00752.x)

Yuen, K. S. L., Johnston, S. J., Martino, F., Sorger, B., Formisano, E., Linden, D. E. J. and Goebel, R. (2012). Pattern classification predicts individuals? responses to affective stimuliTranslational Neuroscience, 3(3), 278-287. (10.2478/s13380-012-0029-6)

2011

Clare, L., Evans, S., Parkinson, C., Woods, R. and Linden, D. E. J. (2011). Goal-Setting in Cognitive Rehabilitation for People with Early-Stage Alzheimer's DiseaseClinical Gerontologist, 34(3), 220-236. (10.1080/07317115.2011.555937)

Fusser, F., Linden, D. E. J., Rahm, B., Hampel, H., Haenschel, C. and Mayer, J. S. (2011). Common capacity-limited neural mechanisms of selective attention and spatial working memory encodingEuropean Journal of Neuroscience, 34(5), 827-838. (10.1111/j.1460-9568.2011.07794.x)

Haenschel, C. and Linden, D. E. J. (2011). Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophreniaBehavioural Brain Research, 216(2), 481-495. (10.1016/j.bbr.2010.08.045)

Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S. and Linden, D. E. J. (2011). Differentiating heavy from light drinkers by neural responses to visual alcohol cues and other motivational stimuliCerebral Cortex, 21(6), 1408-1415. (10.1093/cercor/bhq220)

Jackson, M. C., Morgan, H. M., Shapiro, K. L., Mohr, H. and Linden, D. E. J. (2011). Strategic resource allocation in the human brain supports cognitive coordination of object and spatial working memoryAmerican Journal of Psychiatry, 32(8), 1330-1348. (10.1002/hbm.21112)

Johnston, S., Linden, D. E. J., Healy, D. T., Goebel, R., Habes, I. and Boehm, S. G. (2011). Upregulation of emotion areas through neurofeedback with a focus on positive moodCognitive, Affective, & Behavioral Neuroscience, 11(1), 44-51. (10.3758/s13415-010-0010-1)

Lancaster, T. M., Baird, A., Wolf, C., Jackson, M. C., Johnston, S. J., Donev, R., Thome, J. and Linden, D. E. J. (2011). Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin geneEuropean Neuropsychopharmacology, 21(12), 880-884. (10.1016/j.euroneuro.2011.02.001)

Linden, D. E. J. and Thorne, J. (2011). Modern neuroimaging in psychiatry: towards the integration of functional and molecular informationWorld Journal of Biological Psychiatry, 12(S1), 6-10. (10.3109/15622975.2011.598713)

Linden, D. E. J., Thornton, K., Kuswanto, C. N., Johnston, S. J., van de Ven, V. and Jackson, M. C. (2011). The brain's voices: Comparing nonclinical auditory hallucinations and imageryCerebral Cortex, 21(2), 330-337. (10.1093/cercor/bhq097)

Linden, S. C., Jackson, M. C., Subramanian, L., Healy, D. T. and Linden, D. E. J. (2011). Sad benefit in face working memory: an emotional bias of melancholic depressionJournal of affective disorders, 135(1-3), 251-257. (10.1016/j.jad.2011.08.002)

Morgan, H. M., Muthukumaraswamy, S. D., Hibbs, C. S., Shapiro, K. L., Bracewell, R. M., Singh, K. D. and Linden, D. E. J. (2011). Feature integration in visual working memory: parietal gamma activity is related to cognitive coordinationJournal of Neurophysiology, 106(6), 3185-3194. (10.1152/jn.00246.2011)

Oertel-Knochel, V. and Linden, D. E. J. (2011). Cerebral asymmetry in schizophreniaNeuroscientist, 17(5), 456-467. (10.1177/1073858410386493)

Röder, C. H., Mohr, H. and Linden, D. E. J. (2011). Retention of identity versus expression of emotional faces differs in the recruitment of limbic areasNeuropsychologia, 49(3), 444-453. (10.1016/j.neuropsychologia.2010.11.040)

Subramanian, L., Hindle, J. V., Johnston, S., Roberts, M. V., Husain, M., Goebel, R. and Linden, D. E. J. (2011). Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson's diseaseJournal of Neuroscience, 31(45), 16309-16317. (10.1523/JNEUROSCI.3498-11.2011) pdf

Wolf, C., Jackson, M. C., Kissling, C., Thome, J. and Linden, D. E. J. (2011). Dysbindin-1 genotype effects on emotional working memoryMolecular Psychiatry, 16(2), 145-155. (10.1038/mp.2009.129)

Wolf, C., Linden, S., Jackson, M. C., Healy, D. T., Baird, A., Linden, D. E. J. and Thome, J. (2011). Brain Activity Supporting Working Memory Accuracy in Patients with Paranoid Schizophrenia: A Functional Magnetic Resonance Imaging StudyNeuropsychobiology, 64(2), 93-101. (10.1159/000323800)

2010

Clare, L., Linden, D., Woods, R. T., Whitaker, R., Evans, S. J., Parkinson, C. H., van Paasschen, J., Nelis, S. M., Hoare, Z., Yuen, K. S. L. and Rugg, M. D. (2010). Goal-oriented cognitive rehabilitation for people with early-stage alzheimer disease: A single-blind randomized controlled trial of clinical efficacyAmerican Journal of Geriatric Psychiatry, 18(10), 928-939. (10.1097/JGP.0b013e3181d5792a)

Haenschel, C., Linden, D. E., Bittner, R. A., Singer, W. and Hanslmayr, S. (2010). Alpha Phase Locking Predicts Residual Working Memory Performance in SchizophreniaBiological Psychiatry, 68(7), 595-598. (10.1016/j.biopsych.2010.06.013)

Ihssen, N., Linden, D. E. J. and Shapiro, K. L. (2010). Improving visual short-term memory by sequencing the stimulus arrayPsychonomic Bulletin & Review, 17(5), 680-686. (10.3758/PBR.17.5.680)

Johnston, S. J., Boehm, S. G., Healy, D. T., Goebel, R. and Linden, D. E. J. (2010). Neurofeedback: a promising tool for the self-regulation of emotion networksNeuroImage, 49(1), 1066-1072. (10.1016/j.neuroimage.2009.07.056)

Kuncheva, L. I., Rodriguez, J. J., Plumpton, C. O., Linden, D. E. J. and Johnston, S. J. (2010). Random subspace ensembles for fMRI classificationIEEE Transactions on Medical Imaging, 29(2), 531-542. (10.1109/TMI.2009.2037756)

Linden, S. C., Jackson, M. C., Subramanian, L., Wolf, C., Green, P., Healy, D. T. and Linden, D. E. J. (2010). Emotion-cognition interactions in schizophrenia: implicit and explicit effects of facial expressionNeuropsychologia, 48(4), 997-1002. (10.1016/j.neuropsychologia.2009.11.023)

Mayer, J. S., Roebroeck, A., Maurer, K. and Linden, D. E. J. (2010). Specialization in the default mode: task-induced brain deactivations dissociate between visual working memory and attentionAmerican Journal of Psychiatry, 31(1), 126-139. (10.1002/hbm.20850)

Oertel, V., Knochel, C., Rotarska-Jagiela, A., Schonmeyer, R., Lindner, M., van de Ven, V., Haenschel, C., Uhlhaas, P., Maurer, K. and Linden, D. E. J. (2010). Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimagingJournal of Neuroscience, 30(6), 2289-2299. (10.1523/JNEUROSCI.4575-09.2010) pdf

Oertel, V. and Linden, D. E. J. (2010). Reply to Bell and Halligan Manuscript: "Mental imagery vividness as a trait marker across the schizophrenia spectrum" [Letter]Psychiatry Research, 178(3), 570. (10.1016/j.psychres.2009.06.017)

Rotarska-Jagiela, A., van de Ven, V., Oertel-Knöchel, V., Uhlhaas, P. J., Vogeley, K. and Linden, D. E. J. (2010). Resting-state functional network correlates of psychotic symptoms in schizophreniaSchizophrenia Research, 117(1), 21-30. (10.1016/j.schres.2010.01.001)

SanMiguel, I., Morgan, H. M., Klein, C., Linden, D. E. J. and Escera, C. (2010). On the functional significance of novelty-P3: facilitation by unexpected novel soundsBiological Psychology, 83(2), 143-152. (10.1016/j.biopsycho.2009.11.012)

Subramanian, L., Hindle, J. V., Jackson, M. C. and Linden, D. E. J. (2010). Dopamine boosts memory for angry faces in Parkinson's diseaseMovement Disorders, 25(16), 2792-2799. (10.1002/mds.23420)

2009

Clare, L., van Paasschen, J., Evans, S. J., Parkinson, C., Woods, R. T. and Linden, D. E. J. (2009). Goal-oriented cognitive rehabilitation for an individual with Mild Cognitive Impairment: Behavioural and neuroimaging outcomesNeurocase, 15(4), 318-331. (10.1080/13554790902783116)

Haenschel, C., Bittner, R. A., Waltz, J., Haertling, F., Wibral, M., Singer, W., Linden, D. E. J. and Rodriguez, E. (2009). Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophreniaJournal of Neuroscience, 29(30), 9481-9489. (10.1523/JNEUROSCI.1428-09.2009) pdf

Jackson, M. C., Wu, C., Linden, D. E. J. and Raymond, J. E. (2009). Enhanced visual short-term memory for angry facesJournal of Experimental Psychology: Human Perception and Performance, 35(2), 363-374. (10.1037/a0013895)

Langeslag, S. J. E., Morgan, H. M., Jackson, M. C., Linden, D. E. J. and Van Strien, J. W. (2009). Electrophysiological correlates of improved short-term memory for emotional facesNeuropsychologia, 47(3), 887-896. (10.1016/j.neuropsychologia.2008.12.024)

Linden, D. E. J. and Fallgatter, A. J. (2009). Neuroimaging in psychiatry: from bench to bedsideFrontiers in Human Neuroscience, 3(49), 1-7. (10.3389/neuro.09.049.2009) pdf

Mohr, H. M., Linder, N. S., Linden, D. E. J., Kaiser, J. and Sireteanu, R. (2009). Orientation-specific adaptation to mentally generated lines in human visual cortexNeuroImage, 47(1), 384-391. (10.1016/j.neuroimage.2009.03.045)

Morgan, H. M., Jackson, M. C., Klein, C., Mohr, H., Shapiro, K. L. and Linden, D. E. J. (2009). Neural signatures of stimulus features in visual working memory- a spatiotemporal approachCerebral Cortex, 20(1), 187-197. (10.1093/cercor/bhp094)

Oertel, V., Rotarska-Jagiela, A., van de Ven, V., Haenschel, C., Grube, M., Stangier, U., Maurer, K. and Linden, D. E. J. (2009). Mental imagery vividness as a trait marker across the schizophrenia spectrumPsychiatry Research, 167(1-2), 1-11. (10.1016/j.psychres.2007.12.008)

Rotarska-Jagiela, A., Oertel-Knoechel, V., DeMartino, F., van de Ven, V., Formisano, E., Roebroeck, A., Rami, A., Schoenmeyer, R., Haenschel, C., Hendler, T., Maurer, K., Vogeley, K. and Linden, D. E. J. (2009). Anatomical brain connectivity and positive symptoms of schizophrenia: a diffusion tensor imaging studyPsychiatry Research: Neuroimaging, 174(1), 9-16. (10.1016/j.pscychresns.2009.03.002)

van Paasschen, J., Clare, L., Woods, R. T. and Linden, D. E. J. (2009). Can we change brain functioning with cognition-focused interventions in Alzheimer's disease? The role of functional neuroimagingRestorative Neurology and Neuroscience, 27(5), 473-491. (10.3233/RNN-2009-0494)

2008

Clare, L., Evans, S., Parkinson, C., van Paasschen, J., Nelis, S., Woods, R., Linden, D. E. J. and Rugg, M. (2008). Building resilience through individualised, goal-oriented cognitive rehabilitation in early-stage dementia [Abstract]The Gerontologist, 48(S3), 503. (10.1093/geront/48.Special_Issue_III.1)

Cohen Kadosh, R., Cohen Kadosh, K., Henik, A. and Linden, D. E. J. (2008). Processing conflicting information: facilitation, interference, and functional connectivityNeuropsychologia, 46(12), 2872-2879. (10.1016/j.neuropsychologia.2008.05.025)

Jackson, M. C., Wolf, C., Johnston, S. J., Raymond, J. E. and Linden, D. E. J. (2008). Neural correlates of enhanced visual short-term memory for angry faces: an fmri studyPLoS ONE, 3(10) (10.1371/journal.pone.0003536) pdf

Linden, D. E. J. (2008). Akustische Halluzinationen und funktionelle Bildgebung [Auditory Hallucinations and Functional Imaging]Fortschritte der Neurologie Psychiatrie, 76(S 1), S33-S39. (10.1055/s-2008-1038123)

Linden, D. E. J. (2008). Brain imaging and psychotherapy: methodological considerations and practical implicationsEuropean Archives of Psychiatry and Clinical Neuroscience, 258(S5), 71-75. (10.1007/s00406-008-5023-1)

Linden, D. E. J. (2008). Implementing placebo [Letter]British Medical Journal, 336(7653), 1087. (10.1136/bmj.39577.537778.3A) pdf

Lindner, M., Hundhammer, T., Ciaramidaro, A., Linden, D. E. J. and Mussweiler, T. (2008). The neural substrates of person comparison - An fMRI studyNeuroImage, 40(2), 963-971. (10.1016/j.neuroimage.2007.12.022)

Morgan, H. M., Klein, C., Boehm, S. G., Shapiro, K. L. and Linden, D. E. J. (2008). Working memory load for faces modulates P300, N170, and N250rJournal of Cognitive Neuroscience, 20(6), 989-1002. (10.1162/jocn.2008.20072) pdf

Rotarska-Jagiela, A., Schönmeyer, R., Oertel, V., Haenschel, C., Vogeley, K. and Linden, D. E. J. (2008). The corpus callosum in schizophrenia-volume and connectivity changes affect specific regionsNeuroImage, 39(4), 1522-1532. (10.1016/j.neuroimage.2007.10.063)

Uhlhaas, P. J., Pantel, J., Lanfermann, H., Prvulovic, D., Haenschel, C., Maurer, K. and Linden, D. E. J. (2008). Visual Perceptual Organization Deficits in Alzheimer's DementiaDementia and Geriatric Cognitive Disorders, 25(5), 465-475. (10.1159/000125671)

Wibral, M., Turi, G., Linden, D. E. J., Kaiser, J. and Bledowski, C. (2008). Decomposition of working memory-related scalp ERPs: Crossvalidation of fMRI-constrained source analysis and ICAInternational Journal of Psychophysiology, 67(3), 200-211. (10.1016/j.ijpsycho.2007.06.009)

van de Ven, V., Bledowski, C., Prvulovic, D., Goebel, R., Formisano, E., Di Salle, F., Linden, D. E. J. and Esposito, F. (2008). Visual target modulation of functional connectivity networks revealed by self-organizing group ICAHuman Brain Mapping, 29(12), 1450-1461. (10.1002/hbm.20479)

Full list of publications

2014

Ihssen, N., Linden, D. E. J., Miller, C. E. and Shapiro, K. L. (2014). Neural mechanisms underlying visual short-term memory gain for temporally distinct objectsCerebral Cortex (10.1093/cercor/bhu021)

2013

Habes, I., Krall, S. C., Johnston, S. J., Yuen, K. S. L., Healy, D., Goebel, R., Sorger, B. and Linden, D. E. J. (2013). Pattern classification of valence in depressionNeuroImage: Clinical, 2, 675-683. (10.1016/j.nicl.2013.05.001) pdf

Kedia, G., Lindner, M., Mussweiler, T., Ihssen, N. and Linden, D. E. J. (2013). Brain networks of social comparisonNeuroReport, 24(5), 259-264. (10.1097/WNR.0b013e32835f2069)

Keedwell, P. A. and Linden, D. E. J. (2013). Integrative neuroimaging in mood disordersCurrent Opinion in Psychiatry, 26(1), 27-32. (10.1097/YCO.0b013e32835a0b63)

Morgan, H. M., Jackson, M. C., van Koningsbruggen, M. G., Shapiro, K. L. and Linden, D. E. J. (2013). Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctionsBrain Stimulation, 6(2), 122-129. (10.1016/j.brs.2012.03.001)

Oertel-Knochel, V., Knochel, C., Rotarska-Jagiela, A., Reinke, B., Prvulovic, D., Haenschel, C., Hampel, H. and Linden, D. E. J. (2013). Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrumCerebral Cortex, 23(1), 61-70. (10.1093/cercor/bhr380)

2012

Healy, D. T., Le Noury, J., Linden, S. C., Harris, M., Whitaker, C., Linden, D. E. J., Baker, D. and Roberts, A. P. (2012). The incidence of admissions for schizophrenia and related psychoses in two cohorts: 1875-1924 and 1994-2010British Medical Journal Open, 2(1) (10.1136/bmjopen-2011-000447) pdf

Jackson, M. C., Linden, D. E. J. and Raymond, J. E. (2012). “Distracters” do not always distract: visual working memory for angry faces is enhanced by incidental emotional wordsFrontiers in Psychology, 3 (10.3389/fpsyg.2012.00437) pdf

Johnston, S. J., Linden, D. E. J. and Shapiro, K. L. (2012). Functional imaging reveals working memory and attention interact to produce the attentional blinkJournal of Cognitive Neuroscience, 24(1), 28-38. (10.1162/jocn_a_00054) pdf

Knöchel, C., O'Dwyer, L., Alves, G., Reinke, B., Magerkurth, J., Rotarska-Jagiela, A., Prvulovic, D., Hampel, H., Linden, D. E. J. and Oertel-Knöchel, V. (2012). Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relativesSchizophrenia Research, 140(1-3), 129-135. (10.1016/j.schres.2012.06.001)

Knöchel, C., Oertel-Knöchel, V., Schönmeyer, R., Rotarska-Jagiela, A., van de Ven, V., Prvulovic, D., Haenschel, C., Uhlhaas, P., Pantel, J., Hampel, H. and Linden, D. E. J. (2012). Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relativesNeuroImage, 59(2), 926-934. (10.1016/j.neuroimage.2011.07.088)

Lancaster, T. M., Linden, D. E. J. and Heerey, E. A. (2012). COMT val158met predicts reward responsiveness in humansGenes, Brain and Behavior, 11(8), 986-992. (10.1111/j.1601-183X.2012.00838.x)

Linden, D. E. J., Oosterhof, N. N., Klein, C. and Downing, P. E. (2012). Mapping brain activation and information during category-specific visual working memoryJournal of Neurophysiology, 107(2), 628-639. (10.1152/jn.00105.2011)

Linden, D. E. J., Habes, I., Johnston, S. J., Linden, S., Tatineni, R., Subramanian, L., Sorger, B., Healy, D. T. and Goebel, R. (2012). Real-time self-regulation of emotion networks in patients with depressionPLoS ONE, 7(6) (10.1371/journal.pone.0038115) pdf

Linden, D. E. J. (2012). The biology of psychological disorders. Basingstoke: Palgrave Macmillan.

Linden, D. E. J. (2012). The challenges and promise of neuroimaging in psychiatryNeuron, 73(1), 8-22. (10.1016/j.neuron.2011.12.014)

Oertel-Knöchel, V., Knöchel, C., Matura, S., Rotarska-Jagiela, A., Magerkurth, J., Prvulovic, D., Haenschel, C., Hampel, H. and Linden, D. E. J. (2012). Cortical-basal ganglia imbalance in schizophrenia patients and unaffected first-degree relativesSchizophrenia Research, 138(2-3), 120-127. (10.1016/j.schres.2012.02.029)

Oertel-Knöchel, V., Reinke, B., Hornung, A., Knöchel, C., Matura, S., Knopf, M., Prvulovic, D., O'Dwyer, L., Lindner, M., Rau, A., Hampel, H., Haenschel, C. and Linden, D. E. J. (2012). Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methodsJournal of Nervous and Mental Disease, 200(4), 296-304. (10.1097/NMD.0b013e31824ceef7)

Sreenivas, S., Boehm, S. G. and Linden, D. E. J. (2012). Emotional faces and the default mode networkNeuroscience Letters, 506(2), 229-234. (10.1016/j.neulet.2011.11.012)

Wolf, C. and Linden, D. E. J. (2012). Biological pathways to adaptability - interactions between genome, epigenome, nervous system and environment for adaptive behaviorGenes, Brain and Behavior, 11(1), 3-28. (10.1111/j.1601-183X.2011.00752.x)

Yuen, K. S. L., Johnston, S. J., Martino, F., Sorger, B., Formisano, E., Linden, D. E. J. and Goebel, R. (2012). Pattern classification predicts individuals? responses to affective stimuliTranslational Neuroscience, 3(3), 278-287. (10.2478/s13380-012-0029-6)

2011

Clare, L., Evans, S., Parkinson, C., Woods, R. and Linden, D. E. J. (2011). Goal-Setting in Cognitive Rehabilitation for People with Early-Stage Alzheimer's DiseaseClinical Gerontologist, 34(3), 220-236. (10.1080/07317115.2011.555937)

Fusser, F., Linden, D. E. J., Rahm, B., Hampel, H., Haenschel, C. and Mayer, J. S. (2011). Common capacity-limited neural mechanisms of selective attention and spatial working memory encodingEuropean Journal of Neuroscience, 34(5), 827-838. (10.1111/j.1460-9568.2011.07794.x)

Haenschel, C. and Linden, D. E. J. (2011). Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophreniaBehavioural Brain Research, 216(2), 481-495. (10.1016/j.bbr.2010.08.045)

Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S. and Linden, D. E. J. (2011). Differentiating heavy from light drinkers by neural responses to visual alcohol cues and other motivational stimuliCerebral Cortex, 21(6), 1408-1415. (10.1093/cercor/bhq220)

Jackson, M. C., Morgan, H. M., Shapiro, K. L., Mohr, H. and Linden, D. E. J. (2011). Strategic resource allocation in the human brain supports cognitive coordination of object and spatial working memoryAmerican Journal of Psychiatry, 32(8), 1330-1348. (10.1002/hbm.21112)

Johnston, S., Linden, D. E. J., Healy, D. T., Goebel, R., Habes, I. and Boehm, S. G. (2011). Upregulation of emotion areas through neurofeedback with a focus on positive moodCognitive, Affective, & Behavioral Neuroscience, 11(1), 44-51. (10.3758/s13415-010-0010-1)

Lancaster, T. M., Baird, A., Wolf, C., Jackson, M. C., Johnston, S. J., Donev, R., Thome, J. and Linden, D. E. J. (2011). Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin geneEuropean Neuropsychopharmacology, 21(12), 880-884. (10.1016/j.euroneuro.2011.02.001)

Linden, D. E. J. and Thorne, J. (2011). Modern neuroimaging in psychiatry: towards the integration of functional and molecular informationWorld Journal of Biological Psychiatry, 12(S1), 6-10. (10.3109/15622975.2011.598713)

Linden, D. E. J., Thornton, K., Kuswanto, C. N., Johnston, S. J., van de Ven, V. and Jackson, M. C. (2011). The brain's voices: Comparing nonclinical auditory hallucinations and imageryCerebral Cortex, 21(2), 330-337. (10.1093/cercor/bhq097)

Linden, S. C., Jackson, M. C., Subramanian, L., Healy, D. T. and Linden, D. E. J. (2011). Sad benefit in face working memory: an emotional bias of melancholic depressionJournal of affective disorders, 135(1-3), 251-257. (10.1016/j.jad.2011.08.002)

Morgan, H. M., Muthukumaraswamy, S. D., Hibbs, C. S., Shapiro, K. L., Bracewell, R. M., Singh, K. D. and Linden, D. E. J. (2011). Feature integration in visual working memory: parietal gamma activity is related to cognitive coordinationJournal of Neurophysiology, 106(6), 3185-3194. (10.1152/jn.00246.2011)

Oertel-Knochel, V. and Linden, D. E. J. (2011). Cerebral asymmetry in schizophreniaNeuroscientist, 17(5), 456-467. (10.1177/1073858410386493)

Röder, C. H., Mohr, H. and Linden, D. E. J. (2011). Retention of identity versus expression of emotional faces differs in the recruitment of limbic areasNeuropsychologia, 49(3), 444-453. (10.1016/j.neuropsychologia.2010.11.040)

Subramanian, L., Hindle, J. V., Johnston, S., Roberts, M. V., Husain, M., Goebel, R. and Linden, D. E. J. (2011). Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson's diseaseJournal of Neuroscience, 31(45), 16309-16317. (10.1523/JNEUROSCI.3498-11.2011) pdf

Wolf, C., Jackson, M. C., Kissling, C., Thome, J. and Linden, D. E. J. (2011). Dysbindin-1 genotype effects on emotional working memoryMolecular Psychiatry, 16(2), 145-155. (10.1038/mp.2009.129)

Wolf, C., Linden, S., Jackson, M. C., Healy, D. T., Baird, A., Linden, D. E. J. and Thome, J. (2011). Brain Activity Supporting Working Memory Accuracy in Patients with Paranoid Schizophrenia: A Functional Magnetic Resonance Imaging StudyNeuropsychobiology, 64(2), 93-101. (10.1159/000323800)

2010

Clare, L., Linden, D., Woods, R. T., Whitaker, R., Evans, S. J., Parkinson, C. H., van Paasschen, J., Nelis, S. M., Hoare, Z., Yuen, K. S. L. and Rugg, M. D. (2010). Goal-oriented cognitive rehabilitation for people with early-stage alzheimer disease: A single-blind randomized controlled trial of clinical efficacyAmerican Journal of Geriatric Psychiatry, 18(10), 928-939. (10.1097/JGP.0b013e3181d5792a)

Haenschel, C., Linden, D. E., Bittner, R. A., Singer, W. and Hanslmayr, S. (2010). Alpha Phase Locking Predicts Residual Working Memory Performance in SchizophreniaBiological Psychiatry, 68(7), 595-598. (10.1016/j.biopsych.2010.06.013)

Ihssen, N., Linden, D. E. J. and Shapiro, K. L. (2010). Improving visual short-term memory by sequencing the stimulus arrayPsychonomic Bulletin & Review, 17(5), 680-686. (10.3758/PBR.17.5.680)

Johnston, S. J., Boehm, S. G., Healy, D. T., Goebel, R. and Linden, D. E. J. (2010). Neurofeedback: a promising tool for the self-regulation of emotion networksNeuroImage, 49(1), 1066-1072. (10.1016/j.neuroimage.2009.07.056)

Kuncheva, L. I., Rodriguez, J. J., Plumpton, C. O., Linden, D. E. J. and Johnston, S. J. (2010). Random subspace ensembles for fMRI classificationIEEE Transactions on Medical Imaging, 29(2), 531-542. (10.1109/TMI.2009.2037756)

Linden, S. C., Jackson, M. C., Subramanian, L., Wolf, C., Green, P., Healy, D. T. and Linden, D. E. J. (2010). Emotion-cognition interactions in schizophrenia: implicit and explicit effects of facial expressionNeuropsychologia, 48(4), 997-1002. (10.1016/j.neuropsychologia.2009.11.023)

Mayer, J. S., Roebroeck, A., Maurer, K. and Linden, D. E. J. (2010). Specialization in the default mode: task-induced brain deactivations dissociate between visual working memory and attentionAmerican Journal of Psychiatry, 31(1), 126-139. (10.1002/hbm.20850)

Oertel, V., Knochel, C., Rotarska-Jagiela, A., Schonmeyer, R., Lindner, M., van de Ven, V., Haenschel, C., Uhlhaas, P., Maurer, K. and Linden, D. E. J. (2010). Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimagingJournal of Neuroscience, 30(6), 2289-2299. (10.1523/JNEUROSCI.4575-09.2010) pdf

Oertel, V. and Linden, D. E. J. (2010). Reply to Bell and Halligan Manuscript: "Mental imagery vividness as a trait marker across the schizophrenia spectrum" [Letter]Psychiatry Research, 178(3), 570. (10.1016/j.psychres.2009.06.017)

Rotarska-Jagiela, A., van de Ven, V., Oertel-Knöchel, V., Uhlhaas, P. J., Vogeley, K. and Linden, D. E. J. (2010). Resting-state functional network correlates of psychotic symptoms in schizophreniaSchizophrenia Research, 117(1), 21-30. (10.1016/j.schres.2010.01.001)

SanMiguel, I., Morgan, H. M., Klein, C., Linden, D. E. J. and Escera, C. (2010). On the functional significance of novelty-P3: facilitation by unexpected novel soundsBiological Psychology, 83(2), 143-152. (10.1016/j.biopsycho.2009.11.012)

Subramanian, L., Hindle, J. V., Jackson, M. C. and Linden, D. E. J. (2010). Dopamine boosts memory for angry faces in Parkinson's diseaseMovement Disorders, 25(16), 2792-2799. (10.1002/mds.23420)

2009

Clare, L., van Paasschen, J., Evans, S. J., Parkinson, C., Woods, R. T. and Linden, D. E. J. (2009). Goal-oriented cognitive rehabilitation for an individual with Mild Cognitive Impairment: Behavioural and neuroimaging outcomesNeurocase, 15(4), 318-331. (10.1080/13554790902783116)

Haenschel, C., Bittner, R. A., Waltz, J., Haertling, F., Wibral, M., Singer, W., Linden, D. E. J. and Rodriguez, E. (2009). Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophreniaJournal of Neuroscience, 29(30), 9481-9489. (10.1523/JNEUROSCI.1428-09.2009) pdf

Jackson, M. C., Wu, C., Linden, D. E. J. and Raymond, J. E. (2009). Enhanced visual short-term memory for angry facesJournal of Experimental Psychology: Human Perception and Performance, 35(2), 363-374. (10.1037/a0013895)

Langeslag, S. J. E., Morgan, H. M., Jackson, M. C., Linden, D. E. J. and Van Strien, J. W. (2009). Electrophysiological correlates of improved short-term memory for emotional facesNeuropsychologia, 47(3), 887-896. (10.1016/j.neuropsychologia.2008.12.024)

Linden, D. E. J. and Fallgatter, A. J. (2009). Neuroimaging in psychiatry: from bench to bedsideFrontiers in Human Neuroscience, 3(49), 1-7. (10.3389/neuro.09.049.2009) pdf

Mohr, H. M., Linder, N. S., Linden, D. E. J., Kaiser, J. and Sireteanu, R. (2009). Orientation-specific adaptation to mentally generated lines in human visual cortexNeuroImage, 47(1), 384-391. (10.1016/j.neuroimage.2009.03.045)

Morgan, H. M., Jackson, M. C., Klein, C., Mohr, H., Shapiro, K. L. and Linden, D. E. J. (2009). Neural signatures of stimulus features in visual working memory- a spatiotemporal approachCerebral Cortex, 20(1), 187-197. (10.1093/cercor/bhp094)

Oertel, V., Rotarska-Jagiela, A., van de Ven, V., Haenschel, C., Grube, M., Stangier, U., Maurer, K. and Linden, D. E. J. (2009). Mental imagery vividness as a trait marker across the schizophrenia spectrumPsychiatry Research, 167(1-2), 1-11. (10.1016/j.psychres.2007.12.008)

Rotarska-Jagiela, A., Oertel-Knoechel, V., DeMartino, F., van de Ven, V., Formisano, E., Roebroeck, A., Rami, A., Schoenmeyer, R., Haenschel, C., Hendler, T., Maurer, K., Vogeley, K. and Linden, D. E. J. (2009). Anatomical brain connectivity and positive symptoms of schizophrenia: a diffusion tensor imaging studyPsychiatry Research: Neuroimaging, 174(1), 9-16. (10.1016/j.pscychresns.2009.03.002)

van Paasschen, J., Clare, L., Woods, R. T. and Linden, D. E. J. (2009). Can we change brain functioning with cognition-focused interventions in Alzheimer's disease? The role of functional neuroimagingRestorative Neurology and Neuroscience, 27(5), 473-491. (10.3233/RNN-2009-0494)

2008

Clare, L., Evans, S., Parkinson, C., van Paasschen, J., Nelis, S., Woods, R., Linden, D. E. J. and Rugg, M. (2008). Building resilience through individualised, goal-oriented cognitive rehabilitation in early-stage dementia [Abstract]The Gerontologist, 48(S3), 503. (10.1093/geront/48.Special_Issue_III.1)

Cohen Kadosh, R., Cohen Kadosh, K., Henik, A. and Linden, D. E. J. (2008). Processing conflicting information: facilitation, interference, and functional connectivityNeuropsychologia, 46(12), 2872-2879. (10.1016/j.neuropsychologia.2008.05.025)

Jackson, M. C., Wolf, C., Johnston, S. J., Raymond, J. E. and Linden, D. E. J. (2008). Neural correlates of enhanced visual short-term memory for angry faces: an fmri studyPLoS ONE, 3(10) (10.1371/journal.pone.0003536) pdf

Linden, D. E. J. (2008). Akustische Halluzinationen und funktionelle Bildgebung [Auditory Hallucinations and Functional Imaging]Fortschritte der Neurologie Psychiatrie, 76(S 1), S33-S39. (10.1055/s-2008-1038123)

Linden, D. E. J. (2008). Brain imaging and psychotherapy: methodological considerations and practical implicationsEuropean Archives of Psychiatry and Clinical Neuroscience, 258(S5), 71-75. (10.1007/s00406-008-5023-1)

Linden, D. E. J. (2008). Implementing placebo [Letter]British Medical Journal, 336(7653), 1087. (10.1136/bmj.39577.537778.3A) pdf

Lindner, M., Hundhammer, T., Ciaramidaro, A., Linden, D. E. J. and Mussweiler, T. (2008). The neural substrates of person comparison - An fMRI studyNeuroImage, 40(2), 963-971. (10.1016/j.neuroimage.2007.12.022)

Morgan, H. M., Klein, C., Boehm, S. G., Shapiro, K. L. and Linden, D. E. J. (2008). Working memory load for faces modulates P300, N170, and N250rJournal of Cognitive Neuroscience, 20(6), 989-1002. (10.1162/jocn.2008.20072) pdf

Rotarska-Jagiela, A., Schönmeyer, R., Oertel, V., Haenschel, C., Vogeley, K. and Linden, D. E. J. (2008). The corpus callosum in schizophrenia-volume and connectivity changes affect specific regionsNeuroImage, 39(4), 1522-1532. (10.1016/j.neuroimage.2007.10.063)

Uhlhaas, P. J., Pantel, J., Lanfermann, H., Prvulovic, D., Haenschel, C., Maurer, K. and Linden, D. E. J. (2008). Visual Perceptual Organization Deficits in Alzheimer's DementiaDementia and Geriatric Cognitive Disorders, 25(5), 465-475. (10.1159/000125671)

Wibral, M., Turi, G., Linden, D. E. J., Kaiser, J. and Bledowski, C. (2008). Decomposition of working memory-related scalp ERPs: Crossvalidation of fMRI-constrained source analysis and ICAInternational Journal of Psychophysiology, 67(3), 200-211. (10.1016/j.ijpsycho.2007.06.009)

van de Ven, V., Bledowski, C., Prvulovic, D., Goebel, R., Formisano, E., Di Salle, F., Linden, D. E. J. and Esposito, F. (2008). Visual target modulation of functional connectivity networks revealed by self-organizing group ICAHuman Brain Mapping, 29(12), 1450-1461. (10.1002/hbm.20479)

2007

Bledowski, C., Linden, D. E. J. and Wibral, M. (2007). Combining electrophysiology and functional imaging - different methods for different questions [Letter]Trends in Cognitive Sciences, 11(12), 500-502. (10.1016/j.tics.2007.09.006)

Haenschel, C., Bittner, R. A., Haertling, F., Rotarska-Jagiela, A., Maurer, K., Singer, W. and Linden, D. E. J. (2007). Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imagingArchives of General Psychiatry, 64(11), 1229-1240. (10.1001/archpsyc.64.11.1229)

Jervis, B., Belal, S., Camilleri, K., Cassar, T., Bigan, C., Linden, D. E. J., Michalopoulos, K., Zervakis, M., Besleaga, M., Fabri, S. and Muscat, J. (2007). The independent components of auditory P300 and CNV evoked potentials derived from single-trial recordingsPhysiological Measurement, 28(8), 745-771. (10.1088/0967-3334/28/8/001)

Kadosh, R. C., Kadosh, K. C., Linden, D. E. J., Gevers, W., Berger, A. and Henik, A. (2007). The brain locus of interaction between number and size: a combined functional magnetic resonance imaging and event-related potential studyJournal of Cognitive Neuroscience, 19(6), 957-970. (10.1162/jocn.2007.19.6.957) pdf

Linden, D. E. J. (2007). The Working Memory Networks of the Human BrainThe Neuroscientist, 13(3), 257-267. (10.1177/1073858406298480)

Linden, D. E. J. (2007). What, when, where in the brain? Exploring mental chronometry with brain imaging and electrophysiologyReviews in the Neurosciences, 18(2), 159-171. (10.1515/REVNEURO.2007.18.2.159)

Mayer, J. S., Bittner, R. A., Linden, D. E. J. and Nikolić, D. (2007). Attentional demand influences strategies for encoding into visual working memoryAdvances in Cognitive Psychology, 3(4), 429-448. (10.2478/v10053-008-0007-2)

Mayer, J. S., Bittner, R. A., Nikolić, D., Bledowski, C., Goebel, R. and Linden, D. E. J. (2007). Common neural substrates for visual working memory and attentionNeuroImage, 36(2), 441-453. (10.1016/j.neuroimage.2007.03.007)

Oertel, V., Rotarska-Jagiela, A., van de Ven, V. G., Haenschel, C., Maurer, K. and Linden, D. E. J. (2007). Visual hallucinations in schizophrenia investigated with functional magnetic resonance imagingPsychiatry Research: Neuroimaging, 156(3), 269-273. (10.1016/j.pscychresns.2007.09.004)

Röder, C. H., Michal, M., Overbeck, G., van de Ven, V. G. and Linden, D. E. J. (2007). Pain Response in Depersonalization: A Functional Imaging Study Using Hypnosis in Healthy SubjectsPsychotherapy and Psychosomatics, 76(2), 115-121. (10.1159/000097970)

Sack, A. T., Kohler, A., Bestmann, S., Linden, D. E. J., Dechent, P., Goebel, R. and Baudewig, J. (2007). Imaging the Brain Activity Changes Underlying Impaired Visuospatial Judgments: Simultaneous fMRI, TMS, and Behavioral StudiesCerebral Cortex, 17(12), 2841-2852. (10.1093/cercor/bhm013)

Sack, A. T., Lindner, M. and Linden, D. E. J. (2007). Object- and direction-specific interference between manual and mental rotationPerception & Psychophysics, 69(8), 1435-1449. (10.3758/BF03192958)

2006

Bledowski, C., Kadoshi, K. C., Wibral, M., Rahm, B., Bittner, R. A., Hoechstetter, K., Scherg, M., Maurer, K., Goebel, R. and Linden, D. E. J. (2006). Mental chronometry of working memory retrieval: a combined functional magnetic resonance imaging and event-related potentials approachJournal of Neuroscience, 26(3), 821-829. (10.1523/JNEUROSCI.3542-05.2006) pdf

Blessing, A., Keil, A., Linden, D. E. J., Heim, S. and Ray, W. J. (2006). Acquisition of affective dispositions in dementia patientsNeuropsychologia, 44(12), 2366-2373. (10.1016/j.neuropsychologia.2006.05.004)

Jandl, M., Steyer, J., Weber, M., Linden, D. E. J., Rothmeier, J., Maurer, K. and Kaschka, W. P. (2006). Treating Auditory Hallucinations by Transcranial Magnetic Stimulation: A Randomized Controlled Cross-Over TrialNeuropsychobiology, 53(2), 63-69. (10.1159/000091721)

Linden, D. E. J. (2006). How psychotherapy changes the brain - the contribution of functional neuroimagingMolecular Psychiatry, 11(6), 528-538. (10.1038/sj.mp.4001816)

Mohr, H. M., Goebel, R. and Linden, D. E. J. (2006). Content- and task-specific dissociations of frontal activity during maintenance and manipulation in visual working memoryJournal of Neuroscience, 26(17), 4465-4471. (10.1523/JNEUROSCI.5232-05.2006) pdf

Sack, A. T., Kohler, A., Linden, D. E. J., Goebel, R. and Muckli, L. (2006). The temporal characteristics of motion processing in hMT/V5+: combining fMRI and neuronavigated TMSNeuroimage, 29(4), 1326-1335. (10.1016/j.neuroimage.2005.08.027)

Schönmeyer, R., Prvulovic, D., Rotarska-Jagiela, A., Haenschel, C. and Linden, D. E. J. (2006). Automated segmentation of lateral ventricles from human and primate magnetic resonance images using cognition network technologyMagnetic Resonance Imaging, 24(10), 1377-1387. (10.1016/j.mri.2006.08.013)

Sperling, J., Prvulovic, D., Linden, D. E. J., Singer, W. and Stirn, A. (2006). Neuronal Correlates of Colour-Graphemic Synaesthesia: Afmri StudyCortex, 42(2), 295-303. (10.1016/S0010-9452(08)70355-1)

Uhlhaas, P. J., Linden, D. E. J., Singer, W., Haenschell, C., Lindner, M., Maurer, K. and Rodriguez, E. (2006). Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophreniaJournal of Neuroscience, 26(31), 8168-8175. (10.1523/JNEUROSCI.2002-06.2006) pdf

2005

Kadosh, R. C., Henik, A., Rubinsten, O., Mohr, H., Dori, H., van de Ven, V., Zorzi, M., Hendler, T., Goebel, R. and Linden, D. E. J. (2005). Are numbers special?: The comparison systems of the human brain investigated by fMRINeuropsychologia, 43(9), 1238-1248. (10.1016/j.neuropsychologia.2004.12.017)

Kadosh, R. C., Sagiv, N., Linden, D. E. J., Robertson, L. C., Elinger, G. and Henik, A. (2005). When blue is larger than red: colors influence numerical cognition in synesthesiaJournal of Cognitive Neuroscience, 17(11), 1766-1773. (10.1162/089892905774589181) pdf

Linden, D. E. J. (2005). The P300: Where in the Brain Is It Produced and What Does It Tell Us?The Neuroscientist, 11(6), 563-576. (10.1177/1073858405280524)

Mohr, H. M. and Linden, D. E. J. (2005). Separation of the systems for color and spatial manipulation in working memory revealed by a dual-task procedureJournal of Cognitive Neuroscience, 17(2), 355-366. (10.1162/0898929053124929) pdf

Prvulovic, D., Van de Ven, V., Sack, A. T., Maurer, K. and Linden, D. E. J. (2005). Functional activation imaging in aging and dementiaPsychiatry Research: Neuroimaging, 140(2), 97-113. (10.1016/j.pscychresns.2005.06.006)

Sack, A. T., van de Ven, V. G., Etschenberg, S., Schatz, D. and Linden, D. E. J. (2005). Enhanced vividness of mental imagery as a trait marker of schizophrenia?Schizophrenia Bulletin, 31(1), 97-104. (10.1093/schbul/sbi011)

van de Ven, V. G., Formisano, E., Röder, C. H., Prvulovic, D., Bittner, R. A., Dietz, M. G., Hubl, D., Dierks, T., Federspiel, A., Esposito, F., Di Salle, F., Jansma, B., Goebel, R. and Linden, D. E. J. (2005). The spatiotemporal pattern of auditory cortical responses during verbal hallucinationsNeuroImage, 27(3), 644-655. (10.1016/j.neuroimage.2005.04.041)

2004

Bledowski, C., Prvulovic, D., Hoechstetter, K., Scherg, M., Wibral, M., Goebel, R. and Linden, D. E. J. (2004). Localizing P300 Generators in Visual Target and Distractor Processing: A Combined Event-Related Potential and Functional Magnetic Resonance Imaging StudyThe Journal of Neuroscience, 24(42), 9353-9360. (10.1523/JNEUROSCI.1897-04.2004) pdf

Bledowski, C., Prvulovic, D., Goebel, R., Zanella, F. E. and Linden, D. E. J. (2004). Attentional systems in target and distractor processing: a combined ERP and fMRI studyNeuroimage, 22(2), 530-540. (10.1016/j.neuroimage.2003.12.034)

van de Ven, V. G., Formisano, E., Prvulovic, D., Roeder, C. H. and Linden, D. E. J. (2004). Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during restHuman Brain Mapping, 22(3), 165-178. (10.1002/hbm.20022)

2003

Linden, D. E. J., Bittner, R. A., Muckli, L., Waltz, J. A., Kriegeskorte, N., Goebel, R., Singer, W. and Munk, M. H. (2003). Cortical capacity constraints for visual working memory: dissociation of fMRI load effects in a fronto-parietal networkNeuroImage, 20(3), 1518-1530. (10.1016/j.neuroimage.2003.07.021)

Sack, A. T. and Linden, D. E. J. (2003). Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: possibilities and limitationsBrain Research Reviews, 43(1), 41-56. (10.1016/S0165-0173(03)00191-7)

Schmidt, K. E., Linden, D. E. J., Goebel, R., Zanella, F. E., Lanfermann, H. and Zubcov, A. A. (2003). Striatal activation during blepharospasm revealed by fMRINeurology, 60(11), 1738-1743. (10.1212/01.WNL.0000063306.67984.8C)

2002

Formisano, E., Linden, D. E. J., Di Salle, F., Trojano, L., Esposito, F., Sack, A. T., Grossi, D., Zanella, F. E. and Goebel, R. (2002). Tracking the Mind's Image in the Brain INeuron, 35(1), 185-194. (10.1016/S0896-6273(02)00747-X)

Linden, D. E. J. (2002). Five Hundred Years of Brain ImagesArchives of Neurology, 59(2), 308-313. (10.1001/archneur.59.2.308)

Munk, M. H. J., Linden, D. E. J., Muckli, L., Lanfermann, H., Zanella, F. E., Singer, W. and Goebel, R. (2002). Distributed Cortical Systems in Visual Short-term Memory Revealed by Event-related Functional Magnetic Resonance ImagingCerebral Cortex, 12(8), 866-876. (10.1093/cercor/12.8.866)

Prvulovic, D., Hubl, D., Sack, A., Melillo, L., Maurer, K., Frölich, L., Lanfermann, H., Zanella, F., Goebel, R., Linden, D. E. J. and Dierks, T. (2002). Functional imaging of visuospatial processing in Alzheimer's diseaseNeuroimage, 17(3), 1403-1414. (10.1006/nimg.2002.1271)

Sack, A. T., Hubl, D., Prvulovic, D., Formisano, E., Jandl, M., Zanella, F. E., Maurer, K., Goebel, R., Dierks, T. and Linden, D. E. J. (2002). The experimental combination of rTMS and fMRI reveals the functional relevance of parietal cortex for visuospatial functionsCognitive Brain Research, 13(1), 85-93. (10.1016/S0926-6410(01)00087-8)

Sack, A. T., Sperling, J. M., Prvulovic, D., Formisano, E., Goebel, R., Di Salle, F., Dierks, T. and Linden, D. E. J. (2002). Tracking the Mind's Image in the Brain IINeuron, 35(1), 195-204. (10.1016/S0896-6273(02)00745-6)

Trojano, L., Grossi, D., Linden, D. E. J., Formisano, E., Goebel, R., Cirillo, S., Elefante, R. and Di Salle, F. (2002). Coordinate and categorical judgements in spatial imagery. An fMRI studyNeuropsychologia, 40(10), 1666-1674. (10.1016/S0028-3932(02)00021-0)

2001

Di Salle, F., Formisano, E., Seifritz, E., Linden, D. E. J., Scheffler, K., Saulino, C., Tedeschi, G., Zanella, F. E., Pepino, A., Goebel, R. and Marciano, E. (2001). Functional fields in human auditory cortex revealed by time-resolved fMRI without interference of EPI noiseNeuroimage, 13(2), 328-338. (10.1006/nimg.2000.0683)

2000

Dierks, T., Jelic, V., Pascual-Marqui, R. D., Wahlund, L., Julin, P., Linden, D. E. J., Maurer, K., Winblad, B. and Nordberg, A. (2000). Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's diseaseClinical Neurophysiology, 111(10), 1817-1824. (10.1016/S1388-2457(00)00427-2)

Trojano, L., Grossi, D., Linden, D. E. J., Formisano, E., Hacker, H., Zanella, F. E., Goebel, R. and Di Salle, F. (2000). Matching Two Imagined Clocks: the Functional Anatomy of Spatial Analysis in the Absence of Visual StimulationCerebral Cortex, 10(5), 473-481. (10.1093/cercor/10.5.473)

1999

Di Salle, F., Formisano, E., Linden, D. E. J., Goebel, R., Bonavita, S., Pepino, A., Smaltino, F. and Tedeschi, G. (1999). Exploring brain function with magnetic resonance imagingEuropean Journal of Radiology, 30(2), 84-94. (10.1016/S0720-048X(99)00047-9)

Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H. and Singer, W. (1999). Activation of Heschl's Gyrus during Auditory HallucinationsNeuron, 22(3), 615-621. (10.1016/S0896-6273(00)80715-1)

Linden, D. E. J. (1999). Gabriele Zerbi's De cautelis medicorum and the Tradition of Medical PrudenceBulletin of the History of Medicine, 73(1), 19-37. (10.1353/bhm.1999.0035)

Linden, D. E. J., Prvulovic, D., Formisano, E., Völlinger, M., Zanella, F. E., Goebel, R. and Dierks, T. (1999). The Functional Neuroanatomy of Target Detection: An fMRI Study of Visual and Auditory Oddball TasksCerebral Cortex, 9(8), 815-823. (10.1093/cercor/9.8.815)

Linden, D. E. J., Kallenbach, U., Heinecke, A., Singer, W. and Goebel, R. (1999). The myth of upright vision. A psychophysical and functional imaging study of adaptation to inverting spectaclesPerception, 28(4), 469-481. (10.1068/p2820) pdf

Linden, D. E. J. (1999). The natural and the supernatural in melancholic genius. A debate in sixteenth century Spanish medicine and its antecedentsMedizinhistorisches Journal, 34(3-4), 227-243.

1998

Dierks, T., Linden, D. E. J., Hertel, A., Günther, T., Lanfermann, H., Niesen, A., Frölich, L., Zanella, F. E., Hör, G., Goebel, R. and Maurer, K. (1998). Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington's diseasePsychiatry Research: Neuroimaging, 84(1), 27-35. (10.1016/S0925-4927(98)00040-7)

Goebel, R., Linden, D. E. J., Lanfermann, H., Zanella, F. E. and Singer, W. (1998). Functional imaging of mirror and inverse reading reveals separate coactivated networks for oculomotion and spatial transformationsNeuroreport, 9(4), 713-719.

Linden, D. E. J. (1998). Visual perception: myths and mechanismsTrends in Neurosciences, 21(6), 225-226. (10.1016/S0166-2236(98)01271-5)

Funding

NISCHR, MRC, Wellcome Trust, European Commission

Research group

Neurofeedback/ Brain-Computer Interface Research Group
Dr Niklas Ihssen
Dr Moses Olufemi Sokunbi
Dr Leena Subramanian
http://www.braintrainproject.eu/

Genetic Imaging/ Behavioural Genetics Research Group
(in collaboration with the National Centre for Mental Health, Neuroscience and Mental Health Research Institute and DEFINE Wellcome Trust Strategic Award)
Dr Lisa Brindley
Dr Mark Drakesmith
Dr Thomas Lancaster
Dr Gavin Perry
Dr Katherine Tansey

Research collaborators

Within Cardiff University:
Psychology: Prof Krish Singh, Prof Derek Jones, Prof Greg Maio, Dr Suresh Muthukumuraswamy, Dr Xavier Caseras, Dr Paul Keedwell, Dr John Evans
Psychological Medicine and Clinical Neuroscience: Prof Mike Owen, Prof Julie Williams, Prof Mike O’Donovan, Prof Nick Craddock, Prof David Healy, Prof Peter Holmans,Dr Andrew Pocklington, Dr Stan Zammit

Other UK Universities:
Bangor University: Prof Miles Cox, Dr Christoph Klein
Birmingham University: Prof Jane Raymond, Prof Kimron Shapiro
University College London: Dr Nikolaus Weiskopf, Prof Huw Morris
Kings College London: Dr Jennifer Lau, Dr Kathrin Cohen-Kadosh
Aberdeen University: Dr Margaret Jackson
Swansea University: Dr Stephen Johnston
City University London: Dr Corinna Haenschel
University of East London: Prof Duncan Turner

International:
Maastricht University, Erasmus University Rotterdam, Cologne University, Humboldt University Berlin, Johann Wolfgang Goethe University Frankfurt, University of Coimbra, Twente University, University of Tuebingen, University of Tel Aviv

Postgraduate research interests

Neurofeedback
Genetic imaging
Behavioural pharmacology
Cognitive neuroscience
Biomarkers

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application here.

Current students

George Zacharopoulos

Clinical Fellows (co-supervision)
Dr Tobias Bracht
Dr Joanne Doherty
Dr Duncan McLauchlan

Undergraduate education

Medicine, Classics, Philosophy

Postgraduate education

History of Medicine/Classics (D.Phil., University of Oxford, 2000)
Neuroscience (Dr.med. University of Frankfurt, 1999)
Philosophy (Dr.phil. University of Osnabrueck, 1992)

Awards/external committees

Member of Young Academy, Berlin, Germany, 2003-2008

Employment

Cardiff University since 2011: Professor of Translational Neuroscience (joint appointment between Dept. of Psychological Medicine & Neurology and School of Psychology) and Honorary Consultant Psychiatrist (special interest: Neuropsychiatry)

Bangor University 2004-2010