Dr Kate Langley

Lecturer

Research group:
Developmental & health psychology
Email:
LangleyK@cardiff.ac.uk
Telephone:
+44(0)29 2087 6259
Location:
Tower Building, Park Place

Research summary

Mental health problems in childhood can have far reaching consequences for the individual, their family and society. I am interested in risk factors for such problems, specifically Attention Deficit Hyperactivity Disorder (ADHD), Conduct Disorder and co-occurring problems (such as Autism Spectrum Disorders). I am also interested in how the presentation of these problems changes with age and how different risk factors are associated with the developmental course of disorder.

In order for suggested risk factors to be used for prevention or intervention strategies to improve child outcomes, it is important that we know that there’s a direct causal pathway between the risk factor and disorder. This is difficult to demonstrate for child mental health problems. I am interested in testing these causal pathways using novel or innovative methodology, especially when looking at prenatal or early life risk factors.

Teaching summary

I currently teach on Research Methods within the 1st year Practical Psychology module. I also give tutorials on Social, Perception, cognition and abnormal/clinical psychology.

Selected publications (2008 onwards)

2016

Agha, S., Zammit, S., Thapar, A. and Langley, K. (2016). Maternal psychopathology and offspring clinical outcome: a four year follow-up of boys with ADHDEuropean Child and Adolescent Psychiatry

Fry, C., Langley, K. and Shelton, K. H. (2016). A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or povertyChild Neuropsychology

Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. (2016). Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct DisorderPsychiatry Research, 242, 130-136. (10.1016/j.psychres.2016.05.052) pdf

Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. (2016). Profiling depression in childhood and adolescence: the role of conduct problemsJournal of Child Psychology and Psychiatry, 57(4), 481-490. (10.1111/jcpp.12465) pdf pdf pdf

Sellers, R., Hammerton, G., Harold, G., Mahedy, L., Potter, R., Langley, K., Thapar, A. K., Rice, F., Thapar, A. and Collishaw, S. (2016). Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sampleJournal of Abnormal Psychology, 125(2), 256-266. (10.1037/abn0000080) pdf

Thapar, A., Martin, J., Mick, E., Arias Vasquez, A., Langley, K., Scherer, S., Schacher, R., Crosbie, J., Williams, N. M., Franke, B., Elia, J., Glessner, J., Hakonarson, H., Owen, M. J., Faraone, S., O'Donovan, M. C. and Holmans, P. A. (2016). Psychiatric gene discoveries shape evidence on ADHD's biologyMolecular Psychiatry, 21(9), 1202-1207. (10.1038/mp.2015.163) pdf

van Goozen, S. H. M., Langley, K., Northover, C., Hubble, K., Rubia, K., Schepman, K., O'Donovan, M. C. and Thapar, A. (2016). Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHDJournal of Child Psychology and Psychiatry, 57(4), 472-480. (10.1111/jcpp.12464) pdf

2015

Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. M. (2015). The relative contribution of common and rare genetic variants to ADHDTranslational Psychiatry, 5(2) (10.1038/tp.2015.5) pdf

Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. (2015). Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorderBrain Sciences, 5(3), 369-386. (10.3390/brainsci5030369) pdf

Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. (2015). Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traitsPloS ONE, 1-19. (10.1371/journal.pone.0134417) pdf

Stergiakouli, E., Martin, J., Hamshere, M. L., Langley, K., Evans, D. M., St Pourcain, B., Timpson, N. J., Owen, M. J., O'Donovan, M. C., Thapar, A. and Davey Smith, G. (2015). Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHDJournal of the American Academy of Child and Adolescent Psychiatry, 54(4), 322-327. (10.1016/j.jaac.2015.01.010) pdf

2014

Cooper, M., Langley, K. and Thapar, A. (2014). Antenatal Acetaminophen use and attention-deficit/hyperactivity disorderJAMA Pediatrics, 168(4), 306-307. (10.1001/jamapediatrics.2013.5292)

Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. (2014). Autistic traits in children with ADHD index clinical and cognitive problemsEuropean Child & Adolescent Psychiatry, 23(1), 23-24. (10.1007/s00787-013-0398-6)

Langley, K. and Thapar, A. (2014). Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathwaysInternational Journal of Epidemiology, 43(1), 91-93. (10.1093/ije/dyt275)

2013

Agha, S. S., Zammit, S., Thapar, A. and Langley, K. (2013). Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?European Child & Adolescent Psychiatry, 22(6), 369-377. (10.1007/s00787-013-0378-x)

Ahuja, A., Martin, J., Langley, K. and Thapar, A. (2013). Intellectual disability in children with attention deficit hyperactivity disorderThe Journal of Pediatrics, 163(3), 890-895.e1. (10.1016/j.jpeds.2013.02.043) pdf

Hamshere, M. et al. (2013). High loading of polygenic risk for ADHD in children with comorbid aggressionAmerican Journal of Psychiatry, 170(8), 909-916. (10.1176/appi.ajp.2013.12081129)

Hamshere, M. L., Stergiakouli, E., Langley, K., Martin, J., Holmans, P. A., Kent, L., Owen, M. J., Gill, M., Thapar, A., O'Donovan, M. C. and Craddock, N. J. (2013). Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophreniaBritish Journal of Psychiatry, 203(2), 107-111. (10.1192/bjp.bp.112.117432) pdf

Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. (2013). Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorderSocial Psychiatry and Psychiatric Epidemiology, 48(2), 337-344. (10.1007/s00127-012-0530-9)

Thapar, A., Cooper, M., Eyre, O. and Langley, K. (2013). Practitioner review: what have we learnt about the causes of ADHD?Journal of Child Psychology and Psychiatry, 54(1), 3-16. (10.1111/j.1469-7610.2012.02611.x)

Thapar, A., Langley, K. and Muñoz-Solomando, A. (2013). The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'Journal of Family Therapy, 35(2), 219-223. (10.1111/j.1467-6427.2012.00608.x) pdf

2012

Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. (2012). Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effectsAmerican Journal of Epidemiology, 176(3), 261-268. (10.1093/aje/kwr510)

Stergiakouli, E., Hamshere, M. L., Holmans, P. A., Langley, K., Zaharieva, I., Hawi, Z., Kent, L., Gill, M., Williams, N. M., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2012). Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHDAmerican Journal of Psychiatry, 169(2), 186-194. (10.1176/appi.ajp.2011.11040551) pdf

Williams, N. et al. (2012). Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3American Journal of Psychiatry, 169(2), 195-204. (10.1176/appi.ajp.2011.11060822) pdf

2011

Hassan, A., Agha, S. S., Langley, K. and Thapar, A. (2011). Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 198(3), 195-198. (10.1192/bjp.bp.110.078741)

Hinney, A. et al. (2011). Genome-wide association study in German patients with attention deficit/hyperactivity disorderAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156(8), 888-897. (10.1002/ajmg.b.31246)

Langley, K., Martin, J., Agha, S. S., Davies, C., Stergiakouli, E., Holmans, P. A., Williams, N. M., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2011). Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variantsBritish Journal of Psychiatry, 199(5), 398-403. (10.1192/bjp.bp.111.092130)

Stergiakouli, E., Langley, K., Williams, H., Walters, J. T. R., Williams, N. M., Suren, S., Giegling, I., Wilkinson, L., Owen, M. J., O'Donovan, M. C., Rujescu, D., Thapar, A. and Davies, W. (2011). Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorderGenes Brain and Behavior, 10(3), 334-344. (10.1111/j.1601-183x.2010.00672.x)

2010

Langley, K., Fowler, T. A., Ford, T., Thapar, A. K., van den Bree, M. B., Harold, G. T., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2010). Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 196(3), 235-240. (10.1192/bjp.bp.109.066274)

Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. (2010). Genotype link with extreme antisocial behavior: The contribution of cognitive pathwaysArchives of General Psychiatry, 67(12), 1317-1323. (10.1001/archgenpsychiatry.2010.163)

Neale, B. et al. (2010). Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorderJournal of the American Academy of Child & Adolescent Psychiatry, 49(9), 884-897. (10.1016/j.jaac.2010.06.008)

Thapar, A., Rice, F., Hay, D. F., Boivin, J., Langley, K., van den Bree, M. B., Rutter, M. and Harold, G. T. (2010). Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]Biological psychiatry, 68(4), e13-e14. (10.1016/j.biopsych.2010.01.032)

Williams, N. M., Zaharieva, I., Martin, A. K., Langley, K., Mantripragada, K. K., Fossdal, R., Stefansson, H., Stefansson, K., Magnusson, P., Gudmundsson, O. O., Gustafsson, O., Holmans, P. A., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisThe Lancet, 376(9750), 1401-1408. (10.1016/S0140-6736(10)61109-9)

2009

Fowler, T. A., Langley, K., Rice, F., van den Bree, M. B., Ross, K., Wilkinson, L. S., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2009). Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activityPsychiatric Genetics, 19(6), 312-319. (10.1097/YPG.0b013e3283328df4)

Fowler, T. A., Langley, K., Rice, F., Whittinger, N., Ross, K., van Goozen, S. H. M., Owen, M. J., O'Donovan, M. C., van den Bree, M. B. and Thapar, A. (2009). Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 194(1), 62-67. (10.1192/bjp.bp.107.046870)

Langley, K., Fowler, T. A., Grady, D. L., Moyzis, R. K., Holmans, P. A., van den Bree, M. B., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2009). Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorderEuropean Child & Adolescent Psychiatry, 18(1), 26-32. (10.1007/s00787-008-0698-4)

Thapar, A., Rice, F., Hay, D. F., Boivin, J., Langley, K., van den Bree, M. B., Rutter, M. and Harold, G. T. (2009). Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel designBiological Psychiatry, 66(8), 722-727. (10.1016/j.biopsych.2009.05.032)

2008

Brookes, K. et al. (2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birthAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 94-99. (10.1002/ajmg.b.30562)

Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O'Donovan, M. C., Owen, M. J., Polo Tomas, M., Poulton, R., Rutter, M., Taylor, A., Williams, B. and Thapar, A. (2008). A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorderArchives of General Psychiatry, 65(2), 203-210. (10.1001/archgenpsychiatry.2007.24)

Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. (2008). Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosisChild and Adolescent Mental Health, 13(3), 122-129. (10.1111/j.1475-3588.2007.00466.x)

Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M. B., Craddock, N. J., Kent, L., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2008). Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 49-53. (10.1002/ajmg.b.30571)

Full list of publications

2016

Agha, S., Zammit, S., Thapar, A. and Langley, K. (2016). Maternal psychopathology and offspring clinical outcome: a four year follow-up of boys with ADHDEuropean Child and Adolescent Psychiatry

Fry, C., Langley, K. and Shelton, K. H. (2016). A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or povertyChild Neuropsychology

Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. (2016). Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct DisorderPsychiatry Research, 242, 130-136. (10.1016/j.psychres.2016.05.052) pdf

Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. (2016). Profiling depression in childhood and adolescence: the role of conduct problemsJournal of Child Psychology and Psychiatry, 57(4), 481-490. (10.1111/jcpp.12465) pdf pdf pdf

Sellers, R., Hammerton, G., Harold, G., Mahedy, L., Potter, R., Langley, K., Thapar, A. K., Rice, F., Thapar, A. and Collishaw, S. (2016). Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sampleJournal of Abnormal Psychology, 125(2), 256-266. (10.1037/abn0000080) pdf

Thapar, A., Martin, J., Mick, E., Arias Vasquez, A., Langley, K., Scherer, S., Schacher, R., Crosbie, J., Williams, N. M., Franke, B., Elia, J., Glessner, J., Hakonarson, H., Owen, M. J., Faraone, S., O'Donovan, M. C. and Holmans, P. A. (2016). Psychiatric gene discoveries shape evidence on ADHD's biologyMolecular Psychiatry, 21(9), 1202-1207. (10.1038/mp.2015.163) pdf

van Goozen, S. H. M., Langley, K., Northover, C., Hubble, K., Rubia, K., Schepman, K., O'Donovan, M. C. and Thapar, A. (2016). Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHDJournal of Child Psychology and Psychiatry, 57(4), 472-480. (10.1111/jcpp.12464) pdf

2015

Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. M. (2015). The relative contribution of common and rare genetic variants to ADHDTranslational Psychiatry, 5(2) (10.1038/tp.2015.5) pdf

Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. (2015). Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorderBrain Sciences, 5(3), 369-386. (10.3390/brainsci5030369) pdf

Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. (2015). Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traitsPloS ONE, 1-19. (10.1371/journal.pone.0134417) pdf

Stergiakouli, E., Martin, J., Hamshere, M. L., Langley, K., Evans, D. M., St Pourcain, B., Timpson, N. J., Owen, M. J., O'Donovan, M. C., Thapar, A. and Davey Smith, G. (2015). Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHDJournal of the American Academy of Child and Adolescent Psychiatry, 54(4), 322-327. (10.1016/j.jaac.2015.01.010) pdf

2014

Cooper, M., Langley, K. and Thapar, A. (2014). Antenatal Acetaminophen use and attention-deficit/hyperactivity disorderJAMA Pediatrics, 168(4), 306-307. (10.1001/jamapediatrics.2013.5292)

Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. (2014). Autistic traits in children with ADHD index clinical and cognitive problemsEuropean Child & Adolescent Psychiatry, 23(1), 23-24. (10.1007/s00787-013-0398-6)

Langley, K. and Thapar, A. (2014). Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathwaysInternational Journal of Epidemiology, 43(1), 91-93. (10.1093/ije/dyt275)

2013

Agha, S. S., Zammit, S., Thapar, A. and Langley, K. (2013). Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?European Child & Adolescent Psychiatry, 22(6), 369-377. (10.1007/s00787-013-0378-x)

Ahuja, A., Martin, J., Langley, K. and Thapar, A. (2013). Intellectual disability in children with attention deficit hyperactivity disorderThe Journal of Pediatrics, 163(3), 890-895.e1. (10.1016/j.jpeds.2013.02.043) pdf

Hamshere, M. et al. (2013). High loading of polygenic risk for ADHD in children with comorbid aggressionAmerican Journal of Psychiatry, 170(8), 909-916. (10.1176/appi.ajp.2013.12081129)

Hamshere, M. L., Stergiakouli, E., Langley, K., Martin, J., Holmans, P. A., Kent, L., Owen, M. J., Gill, M., Thapar, A., O'Donovan, M. C. and Craddock, N. J. (2013). Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophreniaBritish Journal of Psychiatry, 203(2), 107-111. (10.1192/bjp.bp.112.117432) pdf

Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. (2013). Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorderSocial Psychiatry and Psychiatric Epidemiology, 48(2), 337-344. (10.1007/s00127-012-0530-9)

Thapar, A., Cooper, M., Eyre, O. and Langley, K. (2013). Practitioner review: what have we learnt about the causes of ADHD?Journal of Child Psychology and Psychiatry, 54(1), 3-16. (10.1111/j.1469-7610.2012.02611.x)

Thapar, A., Langley, K. and Muñoz-Solomando, A. (2013). The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'Journal of Family Therapy, 35(2), 219-223. (10.1111/j.1467-6427.2012.00608.x) pdf

2012

Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. (2012). Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effectsAmerican Journal of Epidemiology, 176(3), 261-268. (10.1093/aje/kwr510)

Stergiakouli, E., Hamshere, M. L., Holmans, P. A., Langley, K., Zaharieva, I., Hawi, Z., Kent, L., Gill, M., Williams, N. M., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2012). Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHDAmerican Journal of Psychiatry, 169(2), 186-194. (10.1176/appi.ajp.2011.11040551) pdf

Williams, N. et al. (2012). Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3American Journal of Psychiatry, 169(2), 195-204. (10.1176/appi.ajp.2011.11060822) pdf

2011

Hassan, A., Agha, S. S., Langley, K. and Thapar, A. (2011). Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 198(3), 195-198. (10.1192/bjp.bp.110.078741)

Hinney, A. et al. (2011). Genome-wide association study in German patients with attention deficit/hyperactivity disorderAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156(8), 888-897. (10.1002/ajmg.b.31246)

Langley, K., Martin, J., Agha, S. S., Davies, C., Stergiakouli, E., Holmans, P. A., Williams, N. M., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2011). Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variantsBritish Journal of Psychiatry, 199(5), 398-403. (10.1192/bjp.bp.111.092130)

Stergiakouli, E., Langley, K., Williams, H., Walters, J. T. R., Williams, N. M., Suren, S., Giegling, I., Wilkinson, L., Owen, M. J., O'Donovan, M. C., Rujescu, D., Thapar, A. and Davies, W. (2011). Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorderGenes Brain and Behavior, 10(3), 334-344. (10.1111/j.1601-183x.2010.00672.x)

2010

Langley, K., Fowler, T. A., Ford, T., Thapar, A. K., van den Bree, M. B., Harold, G. T., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2010). Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 196(3), 235-240. (10.1192/bjp.bp.109.066274)

Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. (2010). Genotype link with extreme antisocial behavior: The contribution of cognitive pathwaysArchives of General Psychiatry, 67(12), 1317-1323. (10.1001/archgenpsychiatry.2010.163)

Neale, B. et al. (2010). Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorderJournal of the American Academy of Child & Adolescent Psychiatry, 49(9), 884-897. (10.1016/j.jaac.2010.06.008)

Thapar, A., Rice, F., Hay, D. F., Boivin, J., Langley, K., van den Bree, M. B., Rutter, M. and Harold, G. T. (2010). Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]Biological psychiatry, 68(4), e13-e14. (10.1016/j.biopsych.2010.01.032)

Williams, N. M., Zaharieva, I., Martin, A. K., Langley, K., Mantripragada, K. K., Fossdal, R., Stefansson, H., Stefansson, K., Magnusson, P., Gudmundsson, O. O., Gustafsson, O., Holmans, P. A., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisThe Lancet, 376(9750), 1401-1408. (10.1016/S0140-6736(10)61109-9)

2009

Fowler, T. A., Langley, K., Rice, F., van den Bree, M. B., Ross, K., Wilkinson, L. S., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2009). Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activityPsychiatric Genetics, 19(6), 312-319. (10.1097/YPG.0b013e3283328df4)

Fowler, T. A., Langley, K., Rice, F., Whittinger, N., Ross, K., van Goozen, S. H. M., Owen, M. J., O'Donovan, M. C., van den Bree, M. B. and Thapar, A. (2009). Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorderBritish Journal of Psychiatry, 194(1), 62-67. (10.1192/bjp.bp.107.046870)

Langley, K., Fowler, T. A., Grady, D. L., Moyzis, R. K., Holmans, P. A., van den Bree, M. B., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2009). Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorderEuropean Child & Adolescent Psychiatry, 18(1), 26-32. (10.1007/s00787-008-0698-4)

Thapar, A., Rice, F., Hay, D. F., Boivin, J., Langley, K., van den Bree, M. B., Rutter, M. and Harold, G. T. (2009). Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel designBiological Psychiatry, 66(8), 722-727. (10.1016/j.biopsych.2009.05.032)

2008

Brookes, K. et al. (2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birthAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 94-99. (10.1002/ajmg.b.30562)

Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O'Donovan, M. C., Owen, M. J., Polo Tomas, M., Poulton, R., Rutter, M., Taylor, A., Williams, B. and Thapar, A. (2008). A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorderArchives of General Psychiatry, 65(2), 203-210. (10.1001/archgenpsychiatry.2007.24)

Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. (2008). Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosisChild and Adolescent Mental Health, 13(3), 122-129. (10.1111/j.1475-3588.2007.00466.x)

Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M. B., Craddock, N. J., Kent, L., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2008). Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 49-53. (10.1002/ajmg.b.30571)

2007

Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. (2007). Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sampleBMC Psychiatry, 7(1), 26-26. (10.1186/1471-244X-7-26)

Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. (2007). Advances in genetic findings on attention deficit hyperactivity disorderPsychological Medicine, 37(12), 1681-1692. (10.1017/S0033291707000773)

Thapar, A., Langley, K., Asherson, P. and Gill, M. (2007). Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspectiveBritish Journal of Psychiatry, 190(1), 1-3. (10.1192/bjp.bp.106.027003)

Thapar, A., Harold, G. T., Holmans, P. A., Rice, F., Langley, K., Aggleton, J. P., Fowler, T., van den Bree, M. B., Owen, M. J. and O'Donovan, M. C. (2007). Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]Archives of General Psychiatry, 64(3), 378-379. (10.1001/archpsyc.64.3.378-b)

Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. (2007). The contribution of gene-environment interaction to psychopathologyDevelopment and Psychopathology, 19(04), 989-1004. (10.1017/S0954579407000491)

Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. (2007). Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorderJournal of the American Academy of Child & Adolescent Psychiatry, 46(2), 179-187. (10.1097/01.chi.0000246066.00825.53)

2006

Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. (2006). Predictors of antisocial behaviour in children with attention deficit hyperactivity disorderEuropean Child & Adolescent Psychiatry, 15(2), 118-125. (10.1007/s00787-006-0511-1)

Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. (2006). Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studiesMolecular Psychiatry, 11(8), 714-20. (10.1038/sj.mp.4001831)

2005

Kent, L., Green, E., Hawi, Z., Kirley, A., Dudbridge, F., Lowe, N., Raybould, R., Langley, K., Bray, N. J., Fitzgerald, M., Owen, M. J., O'Donovan, M. C., Gill, M., Thapar, A. and Craddock, N. J. (2005). Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHDMolecular Psychiatry, 10(10), 939-943. (10.1038/sj.mp.4001696)

Langley, K. (2005). A genetic study of attention deficit hyperactivity disorder: examining environmental influences and phenotypic variation.. PhD Thesis, Cardiff University. pdf

Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. (2005). Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.Minerva Pediatrica, 57(6), 359-371.

Langley, K., Turic, D., Peirce, T. R., Mills, S., van den Bree, M. B., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2005). No support for association between the dopamine transporter (DAT1) gene and ADHDAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 139B(1), 7-10. (10.1002/ajmg.b.30206)

Potter, R., Langley, K. and Sakhuja, D. (2005). All things to all people: what referrers want from their child and adolescent mental health servicePsychiatric Bulletin, 29(7), 262. (10.1192/pb.29.7.262)

Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. (2005). Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A geneJournal of Child Psychology and Psychiatry, 46(10), 1081-1088. (10.1111/j.1469-7610.2005.01533.x)

Thapar, A., Langley, K., Fowler, T., Rice, F., Turic, D., Whittinger, N., Aggleton, J. P., van den Bree, M. B., Owen, M. J. and O'Donovan, M. C. (2005). Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorderArchives of General Psychiatry, 62(11), 1275-1278. (10.1001/archpsyc.62.11.1275)

Turic, D., Langley, K., Williams, H., Norton, N., Williams, N. M., Escott-Price, V., van den Bree, M. B., Owen, M. J., Thapar, A. and O'Donovan, M. C. (2005). A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorderBiological psychiatry, 57(11), 1461-1466. (10.1016/j.biopsych.2005.03.025)

Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. (2005). A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 133B(1), 64-67. (10.1002/ajmg.b.30123)

2004

Fowler, T. A., Thapar, A., Langley, K., Turic, D., Whittinger, N., van den Bree, M. B., Aggleton, J. P., Owen, M. J. and O'Donovan, M. C. (2004). Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 130B(1), 98-98. (10.1002/ajmg.b.30101)

Holmes, J., Lawson, D., Langley, K., Fitzpatrick, H., Trumper, A., Pay, H., Harrington, R. and Thapar, A. (2004). The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validityBritish Journal of Psychiatry, 184(1), 74-78. (10.1192/bjp.184.1.74)

Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2004). Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHDAmerican Journal of Psychiatry, 161(1), 133-138. (10.1176/appi.ajp.161.1.133)

Mills, S., Langley, K., van den Bree, M. B., Street, E., Turic, D., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2004). No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control studyBMC Psychiatry, 4, 15-15. (10.1186/1471-244X-4-15)

Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. (2004). Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHDAmerican Journal of Medical Genetics, 127B(1), 68-72. (10.1002/ajmg.b.20173)

Turic, D., Langley, K., Mills, S., Stephens, M., Lawson, D., Govan, C., Williams, N. M., van den Bree, M. B., Craddock, N. J., Kent, L., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2004). Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHDMolecular Psychiatry, 9(2), 169-173. (10.1038/sj.mp.4001387)

2003

Langley, K., Payton, A., Hamshere, M. L., Pay, H. M., Lawson, D. C., Turic, D., Ollier, W., Worthington, J., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2003). No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorderPsychiatric Genetics, 13(2), 107-110. (10.1097/01.ypg.0000056177.32550.a5)

Lawson, D. C., Turic, D., Langley, K., Pay, H. M., Govan, C. F., Norton, N., Hamshere, M. L., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2003). Association analysis of monoamine oxidase a and attention deficit hyperactivity disorderAmerican Journal of Medical Genetics, 116B(1), 84-89. (10.1002/ajmg.b.10002)

Payton, A., Turic, D., Langley, K., Mills, S., Lawson, D., van den Bree, M. B., Owen, M. J., O'Donovan, M. C., Ollier, W., Worthington, J. and Thapar, A. (2003). No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.Psychiatric Genetics, 13(3), 183-185.

Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. (2003). ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological testsBehavior Genetics, 33(6), 721-721.

2002

Hawi, Z., Dring, M., Kirley, A., Foley, D., Kent, L., Craddock, N. J., Asherson, P., Curran, S., Gould, A., Richards, S., Lawson, D., Pay, H., Turic, D., Langley, K., Owen, M. J., O'Donovan, M. C., Thapar, A., Fitzgerald, M. and Gill, M. (2002). Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sampleMolecular Psychiatry, 7(7), 718-725. (10.1038/sj.mp.4001048)

West, A., Langley, K., Hamshere, M. L., Kent, L., Craddock, N. J., Owen, M. J., O'Donovan, M. C. and Thapar, A. (2002). Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained triosMolecular Psychiatry, 7(9), 962-966. (10.1038/sj.mp.4001129)

Research topics and related papers

Using both clinical samples of children with Attention Deficit Hyperactivity Disorder (ADHD) and other mental health problems (e.g. Conduct disorder, Autism Spectrum Disorders) and epidemiological samples, I am interested in how presentation of disorder and co-morbid problems are influenced by genetic (e.g. Langley et al., 2012a; Hamshere, Langley et al., 2013) and environmental (Langley et al., 2007; Langley et al., 2005; Thapar et al., 2013) risk factors.

I am also interested in the developmental course of ADHD and how presentation changes with age (Langley et al., 2010a), the individual and societal impact of continued problems (Ford et al., 2008; Telford et al., 2013) as well as the risk factors involved with the continuation or remittance of symptoms (Langley et al., 2009; Fowler et al., 2009).

More recently, I have become interested in testing the causal pathways between risk and disorder for prenatal factors (Langley et al., 2012b; Thapar et al., 2009) and putative intermediate phenotypes on the pathway between genes and disorder (Langley et al., 2010b).

Cited references :
Hamshere ML, Langley K et al., (2013) http://www.ncbi.nlm.nih.gov/pubmed/23599091
Telford C et al., (2013) http://www.ncbi.nlm.nih.gov/pubmed/22699685
Thapar A et al., (2013) http://www.ncbi.nlm.nih.gov/pubmed/22963644
Langley K et al., (2012a) http://www.ncbi.nlm.nih.gov/pubmed/22045946
Langley K et al., (2012b) http://www.ncbi.nlm.nih.gov/pubmed/22963644
Langley K et al., (2010a) http://www.ncbi.nlm.nih.gov/pubmed/20194547
Langley K et al., (2010b) http://www.ncbi.nlm.nih.gov/pubmed/21135332
Langley K et al., (2009) http://www.ncbi.nlm.nih.gov/pubmed/18563476
Thapar A et al., (2009) http://www.ncbi.nlm.nih.gov/pubmed/19596120
Ford T et al., (2008) http://onlinelibrary.wiley.com/doi/10.1111/j.1475-3588.2007.00466.x/abstract
Langley K et al., (2007) http://www.ncbi.nlm.nih.gov/pubmed/17584500
Langley K et al., (2005) http://www.ncbi.nlm.nih.gov/pubmed/16523253

Current Research Grant Awards:

2011- 2013: Medical Research Council
Project Grant Antisocial behaviour in young people with ADHD: Identifying risk pathways. (Thapar, van Goozen & Langley) £267,000

2011- 2014: Baily Thomas Charitable Fund  
Project Grant Neuropsychiatric problems in children with intellectual disability. (Thapar, Langley, Williams, O’Donovan, Owen, Kerr, Collishaw) £157,064

Research collaborators

MRC Centre for Neuropsychiatric Genetics and Genomics
National Centre for Mental Health (NCMH)
Child & Adolescent Psychiatry Group, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University

Postgraduate research interests

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application here.

Current students

Sharifah Shameem Agha: Based in the School of Medicine, Sharifah is investigating the role of parental psychopathology on the clinical presentation of ADHD.

Undergraduate education

2000: BA(Hons.) Psychology, Durham University (2:1)

Postgraduate education

2005: PhD, Cardiff University
Thesis title: “A genetic study of ADHD: Examining environmental influences and phenotypic variation”

Awards/external committees

2013: Independent reviewer, US Surgeon General’s Report on smoking (2014)
2012-current: On editorial advisory board for Journal of Child Psychology & Psychiatry
2010: Travel Fellowship, Eunethydis, Amsterdam, The Netherlands
2009-current: Member of the MRC Centre for Neropsychiatric Genetics & Genomics
2005-2006: Wellcome Trust VIP Fellowship, Cardiff University

Employment

Following my undergraduate degree at Durham University, I started working as a Research Psychologist (2001-2003) with Prof Anita Thapar at the University of Wales College of Medicine (now Cardiff University School of Medicine) on a Wellcome Trust funded project investigating susceptibility genes for Attention Deficit Hyperactivity Disorder (ADHD). The project ignited my interest in mental health and understanding the genetic and environmental risk factors associated with such disorders.

This led to my embarking on a PhD, supervised by Prof Thapar and Prof Peter Holmans, investigating how genetic and environmental risk factors for ADHD influence the clinical presentation of the disorder and the interactions between these factors. My work was extended through a Wellcome Trust VIP Fellowship Award (2005-2006).

Whilst continuing to work in the field of genetic and other risk factors for ADHD and other childhood mental health problems, during my post-doctoral position at the School of Medicine (2006-2011), Cardiff University, I became interested in using natural experimental designs to investigate causal pathways between genetic, cognitive and social risk factors and childhood behaviour problems.

After working with Prof Nick Craddock as part of the team establishing the National Centre for Mental Health (NCMH), the first Biomedical Research Centre in Wales (2012-2013), I took up a lecturer post in the School of Psychology, Cardiff University, in August 2013.