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Dr Trevor Humby - BSc (Hons) Sussex, PhD Cambridge

Overview

person name Research Group: Behavioural Neuroscience
Location: Tower Building, Park Place
Email: HumbyT@cardiff.ac.uk
 Telephone: +44(0)29 208 76758

Research Summary

My research interests, as part of the Behavioural Genetics Group, are centred on the effects of imprinted genes and epigenetic changes on brain development and the long-term impact on cognition, behaviour and underlying neuronal development and function.  Genetic imprinting refers to the ‘parent of origin’ specific marking of a gene, where an allele may be expressed or repressed dependant on whether it is derived from the maternal or paternal germline.  This expression/repression is controlled by epigenetic markers (e.g. methylation and acetylation of histones) that govern and configure how a gene is expressed and can hence function.  Imprinted genes are critically important during early development in utero and impact on placental function, controlling the nutrient requirements of the foetus and/or the demands of the foetus upon the mother.  Dysfunction of imprinted genes, by over expression of a ‘normally’ repressed gene or under expression of a ‘normally’ expressed gene, leads to a number of clinical conditions such as Beckwith-Weidemann Syndrome, Prader-Willi syndrome, Angelman’s and may be contributory to other clinical conditions such as ADHD, OCD, autism and schizophrenia 

Other research interests are directed towards understanding the genetic issues that underlie brain function, most notably in terms of diseases such as Alzheimer’s, FTDP-17 and ADHD.  Fronto-temporal Dementia with Parkinson linked to chromosome 17 (FTDP-17) is a form of dementia that affects nearly as many people as Alzheimer's disease and shares a similar pathology but leads to a different range of cognitive and behavioural problems.  Using a transgenic mouse model expressing a human gene incorporating a mutation known to cause FTDP-17, our work in this area is investigating the range of cognitive problems found and how they change with age and then to identifying the underlying neurobiological causes. 

For more information on the Behavioural Genetics Group - visit www.cardiff.bgg.ac.uk

I have also become interested in the role of cognitive dysfunction in dyslexia – most notably working memory impairments, and  have collaborated with Neil Cottrell, a recent graduate from the school (www.lexable.com) and I have an on-going interest in impulse control and decision making.

Teaching Summary

Levels 1 and 2: I teach introductory lectures on individual differences (intelligence, personality and abnormal psychology) at level 1 (PS1016).  At level 2, I teach in the abnormal and clinical psychology module (PSD2018) with lectures covering PTSD, ADHD and neurodegenerative diseases.  I run a level 2 perception practical and also final year projects.  I am module co-ordinator for PS2018 and have responsibility for the summer research opportunities scheme for level 2 students (UROP). I have supervised final year projects with a wide variety of subjects.

Selected Publications (2008 onwards)

2012

Relkovic, D., Humby, T., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. (2012). Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience, 126(3), 488-492. (10.1037/a0028155)

Trent, S., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. (2012). Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology, 37(5), 1267-1274. (10.1038/npp.2011.314)

Trent, S., Dean, R., Veit, B., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. (2012). Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology (10.1016/j.psyneuen.2012.12.002)

2011

Humby, T. and Wilkinson, L. S. (2011). Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology, 11(5), 534-539. (10.1016/j.coph.2011.06.006)

Trent, S., Dennehy, A., Richardson, H., Ojarikre, O. A., Burgoyne, P. S., Humby, T. and Davies, W. (2011). Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology, 37(2), 221-229. (10.1016/j.psyneuen.2011.06.006)

2010

Relkovic, D., Doe, C. M., Humby, T., Johnstone, K. A., Resnick, J. L., Holland, A. J., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. (2010). Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience, 31(1), 156-164. (10.1111/j.1460-9568.2009.07048.x)

2009

Davies, W., Humby, T., Kong, W., Otter, T. L., Burgoyne, P. S. and Wilkinson, L. S. (2009). Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological psychiatry, 66(4), 360-367. (10.1016/j.biopsych.2009.01.001)

Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E., Humby, T., Wilkinson, L. S. and Isles, A. R. (2009). Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics, 18(12), 2140-2148. (10.1093/hmg/ddp137)

2008

Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. (2008). What are imprinted genes doing in the brain?. In: Wilkins, J. ed. Genomic Imprinting. Berlin: Springer, pp. 62-70. (10.1007/978-0-387-77576-0_5)

Doe, C., Garfield, A., Humby, T., Relkovic, D., Wilkinson, L. S. and Isles, A. R. (2008). 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology, 22(s2), 125. (10.1111/j.1472-8206.2008.00601.x)

Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S. R., Coadwell, W. J., Emson, P., Wilkinson, L. S. and Welch, H. C. E. (2008). P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4483-4488. (10.1073/pnas.0712324105)

Publications

Online Publications

Online information about my publications can be obtained via Google Scholar or ResearcherID:

Full List of Publications

2012

Relkovic, D., Humby, T., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. (2012). Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience, 126(3), 488-492. (10.1037/a0028155)

Trent, S., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. (2012). Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology, 37(5), 1267-1274. (10.1038/npp.2011.314)

Trent, S., Dean, R., Veit, B., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. (2012). Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology (10.1016/j.psyneuen.2012.12.002)

2011

Humby, T. and Wilkinson, L. S. (2011). Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology, 11(5), 534-539. (10.1016/j.coph.2011.06.006)

Trent, S., Dennehy, A., Richardson, H., Ojarikre, O. A., Burgoyne, P. S., Humby, T. and Davies, W. (2011). Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology, 37(2), 221-229. (10.1016/j.psyneuen.2011.06.006)

2010

Relkovic, D., Doe, C. M., Humby, T., Johnstone, K. A., Resnick, J. L., Holland, A. J., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. (2010). Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience, 31(1), 156-164. (10.1111/j.1460-9568.2009.07048.x)

2009

Davies, W., Humby, T., Kong, W., Otter, T. L., Burgoyne, P. S. and Wilkinson, L. S. (2009). Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological psychiatry, 66(4), 360-367. (10.1016/j.biopsych.2009.01.001)

Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E., Humby, T., Wilkinson, L. S. and Isles, A. R. (2009). Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics, 18(12), 2140-2148. (10.1093/hmg/ddp137)

2008

Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. (2008). What are imprinted genes doing in the brain?. In: Wilkins, J. ed. Genomic Imprinting. Berlin: Springer, pp. 62-70. (10.1007/978-0-387-77576-0_5)

Doe, C., Garfield, A., Humby, T., Relkovic, D., Wilkinson, L. S. and Isles, A. R. (2008). 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology, 22(s2), 125. (10.1111/j.1472-8206.2008.00601.x)

Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S. R., Coadwell, W. J., Emson, P., Wilkinson, L. S. and Welch, H. C. E. (2008). P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4483-4488. (10.1073/pnas.0712324105)

2007

Davies, W., Humby, T., Isles, A. R., Burgoyne, P. S. and Wilkinson, L. S. (2007). X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry, 61(12), 1351-1360. (10.1016/j.biopsych.2006.08.011)

Lambourne, S. L., Humby, T., Isles, A. R., Emson, P. C., Spillantini, M. G. and Wilkinson, L. S. (2007). Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics, 16(14), 1708-1719. (10.1093/hmg/ddm119)

2006

Colebrooke, R. E., Humby, T., Lynch, P. J., McGowan, D. P., Xia, J. and Emson, P. C. (2006). Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. European Journal of Neuroscience, 24(9), 2622-2630. (10.1111/j.1460-9568.2006.05143.x)

Humby, T. and Wilkinson, L. S. (2006). If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Totowa, NJ: Humana Press , pp. 69-83. (10.1007/978-1-59745-058-4_4)

Isles, A. R. and Humby, T. (2006). Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research, 50(5), 318-325. (10.1111/j.1365-2788.2006.00843.x)

Tofaris, G. K., Reitbock, P. G., Humby, T., Lambourne, S. L., O'Connell, M., Ghetti, B., Gossage, H., Emson, P. C., Wilkinson, L. S., Goedert, M. and Spillantini, M. G. (2006). Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience, 26(15), 3942-3950. (10.1523/JNEUROSCI.4965-05.2006) pdf

2005

Davies, W., Isles, A. R., Smith, R., Karunadasa, D., Burrmann, D., Humby, T., Ojarikre, O., Biggin, C., Skuse, D., Burgoyne, P. S. and Wilkinson, L. S. (2005). Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics, 37(6), 625-629. (10.1038/ng1577)

Humby, T., Wilkinson, L. S. and Dawson, G. (2005). UNIT 8.5H Assaying Aspects of Attention and Impulse Control in Mice Using the 5-Choice Serial Reaction Time Task. In: Current Protocols in Neuroscience. Chichester: Wiley, (10.1002/0471142301.ns0805hs31)

Isles, A. R., Hathway, G. J., Humby, T., de la Riva, C., Kendrick, K. M. and Wilkinson, L. S. (2005). An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience, 22(4), 997-1000. (10.1111/j.1460-9568.2005.04265.x)

Plagge, A., Isles, A. R., Gordon, E., Humby, T., Dean, W., Gritsch, S., Fischer-Colbrie, R., Wilkinson, L. S. and Kelsey, G. (2005). Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology, 25(8), 3019-3026. (10.1128/MCB.25.8.3019-3026.2005)

2004

Isles, A. R., Humby, T., Walters, E. and Wilkinson, L. S. (2004). Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience, 24(30), 6733-6740. (10.1523/JNEUROSCI.1650-04.2004) pdf

2003

Davies, W., Isles, A. R., Burgoyne, P. S., Ward, B. O., Humby, T., de la Riva, C. and Wilkinson, L. S. (2003). Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology, 17(S), A70.

Isles, A. R., Humby, T. and Wilkinson, L. S. (2003). Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology, 170(4), 376-382. (10.1007/s00213-003-1551-6)

2001

Baunez, C., Humby, T., Eagle, D. M., Ryan, L. J., Dunnett, S. B. and Robbins, T. W. (2001). Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience, 13(8), 1609-1616. (10.1046/j.0953-816x.2001.01521.x)

Caine, S. B., Humby, T., Robbins, T. W. and Everitt, B. J. (2001). Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle. Behavioral Neuroscience, 115(4), 880-894. (10.1037/0735-7044.115.4.880)

Mooslehner, K. A., Chan, P. M., Xu, W. M., Liu, L. Z., Smadja, C., Humby, T., Allen, N. D., Wilkinson, L. S. and Emson, P. C. (2001). Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology, 21(16), 5321-5331. (10.1128/MCB.21.16.5321-5331.2001)

2000

Passetti, F., Humby, T., Everitt, B. J. and Robbins, T. W. (2000). Mixed attentional and executive deficits in medial frontal cortex lesioned rats. Psychobiology, 28(2), 261-271.

1999

Carter, R. J., Lione, L. A., Humby, T., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B. and Morton, A. J. (1999). Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience, 19(8), 3248-3257.

Eagle, D. M., Humby, T., Howman, M., Reid-Henry, A., Dunnett, S. B. and Robbins, T. W. (1999). Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology, 27(2), 267-276.

Eagle, D. M., Humby, T., Dunnett, S. B. and Robbins, T. W. (1999). Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience, 113(4), 718-731. (10.1037/0735-7044.113.4.718)

French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V. and Rattray, M. (1999). Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research, 67(1), 124-136. (10.1016/S0169-328X(99)00048-0)

Hall, F. S., Wilkinson, L. S., Humby, T. and Robbins, T. W. (1999). Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse, 32(1), 37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)

Humby, T., Laird, F. M., Davies, W. and Wilkinson, L. S. (1999). Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience, 11(8), 2813-2823. (10.1046/j.1460-9568.1999.00701.x)

1998

Eagle, D. M., Humby, T., Robbins, T. W. and Dunnett, S. B. (1998). A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience, 10(S), 418.

French, S. J., Rattray, M., Humby, T. and Sofronlew, M. (1998). Regulation of hippocampal neurotrophin gene expression by sub-toxic and behaviourally inactive doses of glutamatergic and cholinergic agonists [Abstract]. European Journal of Neuroscience, 10(S), 116.

Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A. and Robbins, T. W. (1998). Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior, 59(4), 859-872. (10.1016/S0091-3057(97)00510-8)

Wilkinson, L. S., Humby, T., Killcross, A. S., Torres, E., Everitt, B. J. and Robbins, T. W. (1998). Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience, 10(3), 1019-1026. (10.1046/j.1460-9568.1998.00119.x)

1997

Brasted, P. J., Humby, T., Dunnett, S. B. and Robbins, T. W. (1997). Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience, 17(22), 8919-8926.

Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. (1997). The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior, 62(2), 281-290. (10.1016/S0031-9384(97)00115-7)

Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. (1997). The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior, 62(2), 299-303. (10.1016/S0031-9384(97)00117-0)

Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. (1997). The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior, 62(2), 291-297. (10.1016/S0031-9384(97)00116-9)

1995

Geyer, M. A., Wilkinson, L. S., Humby, T. and Robbins, T. W. (1995). Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry, 37(9), 634. (10.1016/0006-3223(95)94560-J)

Wilkinson, L. S., Humby, T., Robbins, T. W. and Everitt, B. J. (1995). Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience, 7(10), 2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)

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Research

Research Topics and Related Papers

Research focuses on the role of genetics in neurological disorders and brain function/dysfunction.   This work involves the design and implementation of novel behavioural tasks for assessing cognition in gene manipulation or transgenic mouse models of human disorders and subsequent investigation of the underlying neurobiological changes.  Particular areas of interest:

  • investigating the possible importance of imprinted genes in early development and the putative long term effects dysfunction may have of adult cognition and behaviour (supervision of PhD student Mikael Mikaelsson) in collaboration with Miguel Constancia (University of Cambridge)
  • investigating the mechanisms of gene dysfunction in schizophrenia and effects on cognition (supervision of PhD students Tamara Al-Janabi and Jess Eddy) in collaboration with Mike Owen and Mick O’Donovan (School of Medicine, Cardiff)
  • investigating the relationship between tau-related pathology and cognition in a transgenic mouse model of fronto-temporal dementia in collaboration with Maria Grazia Spillantini (University of Cambridge)
  • investigating the role of imprinted genes on brain function in collaboration with Will Davies, Anthony Isles and Lawrence Wilkinson
  • investigating the role of X and Y chromosome genes in ADHD in collaboration with Will Davies
  • investigating the electrophysiological signatures of different brain regions during performance of paradigms which assess impulse control (SARTE consortium).

Funding

Genes and Development Summer Studentship, The Genetics Society: Investigating social memory and interactions in mouse models of schizophrenia. 22/5/12, £3,000

SARTRE research consortium:  The neurophysiological basis of response inhibition and its use in diagnosis of complex frontal cortical dysfunction.  1/4/10, £30,000

Research Group

I collaborate closely with other members of the Behavioural Genetics Group that was formed when on moving from the Babraham Institute in 2006.  The BGG includes:

Professor Lawrence Wilkinson

Dr Anthony Isles

Dr Will Davies

Dr Jo Haddon

Research Collaborators

In addition to other members of the BGG I also work with the following people at other institutions:

Dr Matt Jones (Bristol, SARTRE consortium)

Dr Lynsey Forsyth (Bristol, SARTRE consortium)

Dr Liz Coulthard (Bristol, SARTRE consortium)

Dr Miguel Constancia (University of Cambridge): investigating the possible importance of imprinted genes in early development and the putative long term effects dysfunction may have of adult cognition and behaviour

Prof Maria Grazia Spillantini (University of Cambridge): investigating the relationship between tau-related pathology and cognition in a transgenic mouse model of fronto-temporal dementia

Postgraduate Students

Postgraduate Research Interests

I am interested in how genetic background and early environmental factors interact to give rise to long term, enduring effects on brain function and behaviour. My research at the moment focuses on a recently discovered class of genes, called imprinted genes. Imprinted genes are odd in that expression only occurs from either the allele inherited from mum or the allele inherited from dad as opposed to the major majority of genes where both copies are expressed equally irrespective of their parental origin. The existence of imprinted genes raises many fascinating evolutionary issues but they are of most immediate interest for me because of their key role in growth and development. In my current research I am testing the idea that imprinted gene action, in both the placenta and brain, can influence cognitive and behavioural outcomes via effects on pre- and postnatal growth. Previously, I have had interests in genetic polymorphisms influencing response control and gene mutations underlying familial dementias.

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application here.

Current Students

Claire Dent (starting 2010), co-supervisor with Anthony Isles

Jessica Eddy (started 2009) co-supervisor with Lawrence Wilkinson, Mike Owen

Previous Students

Tamara al-Janabi (started 2007) co-supervisor with Lawrence Wilkinson, Mike Owen

Mikael Mikaelsson (started 2006) co-supervisor with Lawrence Wilkinson

Biography

Undergraduate Education

Bachelor of Science (with Honours) in Neurobiology, University of Sussex

Postgraduate Education

Doctor of Philosophy, University of Cambridge.
Thesis title, ‘Effects of mutations of genes involved in familial Alzheimer’s disease on behavioural and neural functioning’.
Supervisor: Dr. Lawrence Wilkinson.

Prizes

Recipient of Oon Khye Beng Ch’hia Tsio prize research scholarship for preventative medicine offered by Downing College, Cambridge. (1998-2001).

Memberships

British Association of Psychopharmacology (BAP, since 1990)

British Neuroscience Association (BNA, since 1989)

Society for Neuroscience (SFN, since 2000)

The Genetics Society (since 2009)

Other

Reviewer of submitted manuscripts for European Journal of Neuroscience, Psychopharmacology, Behavioural Brain Research, Journal of Psychopharmacology