Professor John Aggleton, School of Psychology, Cardiff University

Overview

Research Group: Behavioural Neuroscience
Location: Tower Building, Park Place
Email: Aggleton@cardiff.ac.uk
Telephone: +44(0)29 208 74563

Research Summary

My research examines how brain regions interact to support different forms of memory. This systems level analysis of memory is ultimately concerned with understanding the human brain, and so includes clinical studies of people with memory problems, e.g. amnesia. A major part of my work, however, involves animal models of amnesic conditions. An integral part of this endeavour is to compare and contrast different forms of memory, e.g. the recall of day-to-day events versus the recognition of events, along with the brain systems that appear to support these forms of memory. A particular goal is to relate the amnesias associated with damage to different regions of the brain, and to test various models that explain their similarities and differences.

Teaching Summary

I am currently the module leader for the Year 2 course on Abnormal Psychology (PS2008). I also lecture on a Year 3 module that examines the neuropsychology of memory (Memory Processes and Memory Disorders, PS3208).

Selected Publications (2008 onwards)

2013

Jones, D. K., Christiansen, K. Y., Chapman, R. J. and Aggleton, J. (2013). Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for europsychological investigations.. Neuropsychologia, 51(1), 67-78. (10.1016/j.neuropsychologia.2012.11.018)

Metzler-Baddeley, C., Baddeley, R. J., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. (2013). Individual differences in fornix microstructure and body mass index. PLoS ONE, 8(3) (10.1371/journal.pone.0059849)

2012

Aggleton, J. P., Brown, M. W. and Albasser, M. M. (2012). Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene imaging. Neuropsychologia, 50(13), 3141-3155. (10.1016/j.neuropsychologia.2012.05.018)

Aggleton, J. P., Wright, N. F., Vann, S. D. and Saunders, R. C. (2012). Medial temporal lobe projections to the retrosplenial cortex of the macaque monkey brain. Hippocampus, 22(9), 1883-1900. (10.1002/hipo.22024)

Aggleton, J. P. (2012). Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function. Neuroscience & Biobehavioral Reviews, 36(7), 1579-1596. (10.1016/j.neubiorev.2011.09.005)

Brown, M. W., Barker, G. R. I., Aggleton, J. P. and Warburton, E. C. (2012). What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory. Neuropsychologia, 50(13), 3122-3140. (10.1016/j.neuropsychologia.2012.07.034)

Metzler-Baddeley, C., Jones, D. K., Steventon, J., Westacott, L., Aggleton, J. P. and O'Sullivan, M. (2012). Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience, 32(49), 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)

Metzler-Baddeley, C., Hunt, S., Jones, D. K., Leemans, A., Aggleton, J. P. and O'Sullivan, M. (2012). Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology, 79(23), 2233-2240. (10.1212/WNL.0b013e31827689e8)

Oitzl, M. S., Schwabe, L. and Aggleton, J. P. (2012). Memory formation: Its changing face [Editorial]. Neuroscience & Biobehavioral Reviews, 36(7), 1577-1578. (10.1016/j.neubiorev.2012.03.004)

Saunders, R. C., Vann, S. D. and Aggleton, J. P. (2012). Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis). Journal of Comparative Neurology, 520(6), 1128-1145. (10.1002/cne.22740)

2011

Aggleton, J. P., Amin, E., Jenkins, T. A., Pearce, J. M. and Ward-Robinson, J. (2011). Lesions in the anterior thalamic nuclei of rats do not disrupt acquisition of stimulus sequence learning. The Quarterly Journal of Experimental Psychology, 64(1), 65-73. (10.1080/17470218.2010.495407)

Aggleton, J. P., Dumont, J. R. and Warburton, E. C. (2011). Unraveling the contributions of the diencephalon to recognition memory: A review. Learning & Memory, 18(6), 384-400. (10.1101/lm.1884611)

Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. (2011). Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects. European Journal of Neuroscience, 34(2), 331-342. (10.1111/j.1460-9568.2011.07755.x)

Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. (2011). Separate but interacting recognition memory systems for different senses: The role of the rat perirhinal cortex. Learning & Memory, 18(7), 435-443. (10.1101/lm.2132911)

Metzler-Baddeley, C., Jones, D. K., Belaroussi, B., Aggleton, J. P. and O'Sullivan, M. (2011). Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience, 31(37), 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)

Metzler-Baddeley, C., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. (2011). The fornix in ageing and memory decline: a diffusion MRI tractography study [Abstract]. Journal of Neurology, 258(S1), 18-18. (10.1007/s00415-011-6026-9)

Poirier, G. L., Amin, E., Good, M. A. and Aggleton, J. P. (2011). Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience, 174, 71-83. (10.1016/j.neuroscience.2010.11.025)

Tinsley, C. J., Fontaine-Palmer, N. S., Vincent, M., Endean, E. P. E., Aggleton, J. P., Brown, M. W. and Warburton, E. C. (2011). Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex. Learning & Memory, 18(7), 484-492. (10.1101/lm.2274911)

Tsanov, M., Wright, N. F., Vann, S. D., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Hippocampal inputs mediate theta-related plasticity in anterior thalamus. Neuroscience, 187, 52-62. (10.1016/j.neuroscience.2011.03.055)

Tsanov, M., Chah, E., Wright, N. F., Vann, S. D., Reilly, R., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Oscillatory entrainment of thalamic neurons by theta rhythm in freely moving rats. Journal of Neurophysiology, 105(1), 4-17. (10.1152/jn.00771.2010)

Tsanov, M., Vann, S. D., Erichsen, J. T., Wright, N. F., Aggleton, J. P. and O'Mara, S. M. (2011). Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus. Hippocampus, 21(1), 1-8. (10.1002/hipo.20749)

Tsanov, M., Chah, E., Vann, S. D., Reilly, R. B., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Theta-modulated head direction cells in the rat anterior thalamus. The Journal of Neuroscience, 31(26), 9489-9502. (10.1523/JNEUROSCI.0353-11.2011)

Vann, S. D., Erichsen, J. T., O'Mara, S. M. and Aggleton, J. P. (2011). Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function. Hippocampus, 21(9), 945-967. (10.1002/hipo.20796)

2010

Aggleton, J. P., O'Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M. and Erichsen, J. T. (2010). Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. European Journal of Neuroscience, 31(12), 2292-2307. (10.1111/j.1460-9568.2010.07251.x)

Aggleton, J. P., Albasser, M. M., Aggleton, D. J., Poirier, G. L. and Pearce, J. M. (2010). Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition. Behavioral Neuroscience, 124(1), 55-68. (10.1037/a0018320)

Aggleton, J. P. (2010). Understanding retrosplenial amnesia: Insights from animal studies. Neuropsychologia, 48(8), 2328-2338. (10.1016/j.neuropsychologia.2009.09.030)

Albasser, M. M., Chapman, R. J., Amin, E., Iordanova, M. D., Vann, S. D. and Aggleton, J. P. (2010). New behavioral protocols to extend our knowledge of rodent object recognition memory. Learning & Memory, 17(8), 407-419. (10.1101/lm.1879610)

Albasser, M. M., Poirier, G. L. and Aggleton, J. P. (2010). Qualitatively different modes of perirhinal–hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging. European Journal of Neuroscience, 31(1), 134-147. (10.1111/j.1460-9568.2009.07042.x)

Amin, E., Wright, N. F., Poirier, G. L., Thomas, K. L., Erichsen, J. T. and Aggleton, J. P. (2010). Selective lamina dysregulation in granular retrosplenial cortex (area 29) after anterior thalamic lesions: an in situ hybridization and trans-neuronal tracing study in rats. Neuroscience, 169 (3), 1255-1267. (10.1016/j.neuroscience.2010.05.055)

Brown, M. W., Warburton, E. C. and Aggleton, J. P. (2010). Recognition memory: Material, processes, and substrates. Hippocampus, 20(11), 1228-1244. (10.1002/hipo.20858)

Horne, M. R., Iordanova, M. D., Albasser, M. M., Aggleton, J. P., Honey, R. C. and Pearce, J. M. (2010). Lesions of the perirhinal cortex do not impair integration of visual and geometric information in rats. Behavioral Neuroscience, 124(3), 311-320. (10.1037/a0019287)

Pothuizen, H. H. J., Davies, M., Aggleton, J. P. and Vann, S. D. (2010). Effects of selective granular retrosplenial cortex lesions on spatial working memory in rats. Behavioural Brain Research, 208(2), 566-575. (10.1016/j.bbr.2010.01.001)

Wright, N. F., Erichsen, J. T., Vann, S. D., O'Mara, S. M. and Aggleton, J. P. (2010). Parallel but separate inputs from limbic cortices to the mammillary bodies and anterior thalamic nuclei in the rat. The Journal of Comparative Neurology, 518(12), 2334-2354. (10.1002/cne.22336)

2009

Aggleton, J. P., Poirier, G. L., Aggleton, H. S., Vann, S. D. and Pearce, J. M. (2009). Lesions of the fornix and anterior thalamic nuclei dissociate different aspects of hippocampal-dependent spatial learning: Implications for the neural basis of scene learning. Behavioral Neuroscience, 123(3), 504-519. (10.1037/a0015404)

Albasser, M. M., Davies, M., Futter, J. E. and Aggleton, J. P. (2009). Magnitude of the object recognition deficit associated with perirhinal cortex damage in rats: Effects of varying the lesion extent and the duration of the sample period. Behavioral Neuroscience, 123(1), 115-124. (10.1037/a0013829)

Denby, C. E., Vann, S. D., Tsivilis, D., Aggleton, J. P., Montaldi, D., Roberts, N. and Mayes, A. R. (2009). The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst. American Journal of Neuroradiology, 30(4), 736-743. (10.3174/ajnr.A1424)

Garden, D. L. F., Massey, P. V., Caruana, D. A., Johnson, B., Warburton, E. C., Aggleton, J. P. and Bashir, Z. I. (2009). Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia. Brain, 132(7), 1847-1857. (10.1093/brain/awp090)

Iordanova, M. D., Burnett, D. J., Aggleton, J. P., Good, M. A. and Honey, R. C. (2009). The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. European Journal of Neuroscience, 30(11), 2177-2189. (10.1111/j.1460-9568.2009.07010.x)

Poirier, G. L. and Aggleton, J. P. (2009). Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity. Neuroscience, 160(2), 452-469. (10.1016/j.neuroscience.2009.02.021)

Pothuizen, H. H. J., Davies, M., Albasser, M. M., Aggleton, J. P. and Vann, S. D. (2009). Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats. European Journal of Neuroscience, 30(5), 877-888. (10.1111/j.1460-9568.2009.06881.x)

Robinson, J., Sanderson, D. J., Aggleton, J. P. and Jenkins, T. A. (2009). Suppression to visual, auditory, and gustatory stimuli habituates normally in rats with excitotoxic lesions of the perirhinal cortex. Behavioral Neuroscience, 123(6), 1238-1250. (10.1037/a0017444)

Vann, S. D., Tsivilis, D., Denby, C. E., Quamme, J. R., Yonelinas, A. P., Aggleton, J. P., Montaldi, D. and Mayes, A. R. (2009). Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods. Proceedings of the National Academy of Sciences, 106(13), 5442-5447. (10.1073/pnas.0812097106)

Vann, S. D., Aggleton, J. P. and Maguire, E. A. (2009). What does the retrosplenial cortex do?. Nature Reviews Neuroscience, 10(11), 792-802. (10.1038/nrn2733)

2008

Aggleton, J. P. (2008). Understanding anterograde amnesia: Disconnections and hidden lesions. Quarterly Journal of Experimental Psychology, 61(10), 1441-1471. (10.1080/17470210802215335)

Aggleton, J. P., Saunders, R. C. and Vann, S. D. (2008). Using hippocampal amnesia to understand the neural basis of diencephalic amnesia. In: Dere, E. et al. eds. Handbook of Episodic Memory, Vol 18. Amsterdam: Elsevier, pp. 503-519. (10.1016/S1569-7339(08)00227-0)

Denby, C., Vann, S. D., Tsivilis, D., Aggleton, J. P., Mayes, A., Sluming, V., Roberts, N. and Montaldi, D. (2008). MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle. Neuroscience Imaging, 2(3), 109-125.

Denby, C., Vann, S. D., Tsivilis, D., Mayes, A., Montaldi, D. and Aggleton, J. P. (2008). Neuroimaging of the fornix: present and future. Neuroscience Imaging, 2(3), 135-148.

Kyd, R. J., Pearce, J. M., Haselgrove, M., Amin, E. and Aggleton, J. P. (2008). The effects of hippocampal system lesions on a novel temporal discrimination task for rats. Behavioural Brain Research, 187(1), 159-171. (10.1016/j.bbr.2007.09.010 )

Poirier, G. L., Shires, K. L., Sugden, D., Amin, E., Thomas, K. L., Carter, D. A. and Aggleton, J. P. (2008). Anterior thalamic lesions produce chronic and profuse transcriptional deregulation in retrosplenial cortex: A model of retrosplenial hypoactivity and covert pathology. Thalamus and Related Systems, 4 (1), 59-77.

Poirier, G. L., Amin, E. and Aggleton, J. P. (2008). Qualitatively different hippocampal subfield engagement emerges with mastery of a spatial memory task by rats. The Journal of Neuroscience, 28(5), 1034-1045. (10.1523/JNEUROSCI.4607-07.2008)

Pothuizen, H. H. J., Aggleton, J. P. and Vann, S. D. (2008). Do rats with retrosplenial cortex lesions lack direction?. European Journal Of Neuroscience, 28(12), 2486-2498. (10.1111/j.1460-9568.2008.06550.x)

Shires, K. L. and Aggleton, J. P. (2008). Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions. European Journal Of Neuroscience, 28(5), 982-996. (10.1111/j.1460-9568.2008.06402.x )

Tsivilis, D., Vann, S. D., Denby, C., Roberts, N., Mayes, A. R., Montaldi, D. and Aggleton, J. P. (2008). A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Nature Neuroscience, 11(7), 834-842. (10.1038/nn.2149)

Publications

Online Publications

Online information about my publications can be obtained via Google Scholar:

Full List of Publications

Forthcoming

2013

Jones, D. K., Christiansen, K. Y., Chapman, R. J. and Aggleton, J. (2013). Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for europsychological investigations.. Neuropsychologia, 51(1), 67-78. (10.1016/j.neuropsychologia.2012.11.018)

Metzler-Baddeley, C., Baddeley, R. J., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. (2013). Individual differences in fornix microstructure and body mass index. PLoS ONE, 8(3) (10.1371/journal.pone.0059849)

2012

Aggleton, J. P., Brown, M. W. and Albasser, M. M. (2012). Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene imaging. Neuropsychologia, 50(13), 3141-3155. (10.1016/j.neuropsychologia.2012.05.018)

Aggleton, J. P., Wright, N. F., Vann, S. D. and Saunders, R. C. (2012). Medial temporal lobe projections to the retrosplenial cortex of the macaque monkey brain. Hippocampus, 22(9), 1883-1900. (10.1002/hipo.22024)

Aggleton, J. P. (2012). Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function. Neuroscience & Biobehavioral Reviews, 36(7), 1579-1596. (10.1016/j.neubiorev.2011.09.005)

Brown, M. W., Barker, G. R. I., Aggleton, J. P. and Warburton, E. C. (2012). What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory. Neuropsychologia, 50(13), 3122-3140. (10.1016/j.neuropsychologia.2012.07.034)

Metzler-Baddeley, C., Jones, D. K., Steventon, J., Westacott, L., Aggleton, J. P. and O'Sullivan, M. (2012). Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience, 32(49), 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)

Metzler-Baddeley, C., Hunt, S., Jones, D. K., Leemans, A., Aggleton, J. P. and O'Sullivan, M. (2012). Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology, 79(23), 2233-2240. (10.1212/WNL.0b013e31827689e8)

Oitzl, M. S., Schwabe, L. and Aggleton, J. P. (2012). Memory formation: Its changing face [Editorial]. Neuroscience & Biobehavioral Reviews, 36(7), 1577-1578. (10.1016/j.neubiorev.2012.03.004)

Saunders, R. C., Vann, S. D. and Aggleton, J. P. (2012). Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis). Journal of Comparative Neurology, 520(6), 1128-1145. (10.1002/cne.22740)

2011

Aggleton, J. P., Amin, E., Jenkins, T. A., Pearce, J. M. and Ward-Robinson, J. (2011). Lesions in the anterior thalamic nuclei of rats do not disrupt acquisition of stimulus sequence learning. The Quarterly Journal of Experimental Psychology, 64(1), 65-73. (10.1080/17470218.2010.495407)

Aggleton, J. P., Dumont, J. R. and Warburton, E. C. (2011). Unraveling the contributions of the diencephalon to recognition memory: A review. Learning & Memory, 18(6), 384-400. (10.1101/lm.1884611)

Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. (2011). Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects. European Journal of Neuroscience, 34(2), 331-342. (10.1111/j.1460-9568.2011.07755.x)

Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. (2011). Separate but interacting recognition memory systems for different senses: The role of the rat perirhinal cortex. Learning & Memory, 18(7), 435-443. (10.1101/lm.2132911)

Metzler-Baddeley, C., Jones, D. K., Belaroussi, B., Aggleton, J. P. and O'Sullivan, M. (2011). Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience, 31(37), 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)

Metzler-Baddeley, C., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. (2011). The fornix in ageing and memory decline: a diffusion MRI tractography study [Abstract]. Journal of Neurology, 258(S1), 18-18. (10.1007/s00415-011-6026-9)

Poirier, G. L., Amin, E., Good, M. A. and Aggleton, J. P. (2011). Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience, 174, 71-83. (10.1016/j.neuroscience.2010.11.025)

Tinsley, C. J., Fontaine-Palmer, N. S., Vincent, M., Endean, E. P. E., Aggleton, J. P., Brown, M. W. and Warburton, E. C. (2011). Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex. Learning & Memory, 18(7), 484-492. (10.1101/lm.2274911)

Tsanov, M., Wright, N. F., Vann, S. D., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Hippocampal inputs mediate theta-related plasticity in anterior thalamus. Neuroscience, 187, 52-62. (10.1016/j.neuroscience.2011.03.055)

Tsanov, M., Chah, E., Wright, N. F., Vann, S. D., Reilly, R., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Oscillatory entrainment of thalamic neurons by theta rhythm in freely moving rats. Journal of Neurophysiology, 105(1), 4-17. (10.1152/jn.00771.2010)

Tsanov, M., Vann, S. D., Erichsen, J. T., Wright, N. F., Aggleton, J. P. and O'Mara, S. M. (2011). Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus. Hippocampus, 21(1), 1-8. (10.1002/hipo.20749)

Tsanov, M., Chah, E., Vann, S. D., Reilly, R. B., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. (2011). Theta-modulated head direction cells in the rat anterior thalamus. The Journal of Neuroscience, 31(26), 9489-9502. (10.1523/JNEUROSCI.0353-11.2011)

Vann, S. D., Erichsen, J. T., O'Mara, S. M. and Aggleton, J. P. (2011). Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function. Hippocampus, 21(9), 945-967. (10.1002/hipo.20796)

2010

Aggleton, J. P., O'Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M. and Erichsen, J. T. (2010). Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. European Journal of Neuroscience, 31(12), 2292-2307. (10.1111/j.1460-9568.2010.07251.x)

Aggleton, J. P., Albasser, M. M., Aggleton, D. J., Poirier, G. L. and Pearce, J. M. (2010). Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition. Behavioral Neuroscience, 124(1), 55-68. (10.1037/a0018320)

Aggleton, J. P. (2010). Understanding retrosplenial amnesia: Insights from animal studies. Neuropsychologia, 48(8), 2328-2338. (10.1016/j.neuropsychologia.2009.09.030)

Albasser, M. M., Chapman, R. J., Amin, E., Iordanova, M. D., Vann, S. D. and Aggleton, J. P. (2010). New behavioral protocols to extend our knowledge of rodent object recognition memory. Learning & Memory, 17(8), 407-419. (10.1101/lm.1879610)

Albasser, M. M., Poirier, G. L. and Aggleton, J. P. (2010). Qualitatively different modes of perirhinal–hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging. European Journal of Neuroscience, 31(1), 134-147. (10.1111/j.1460-9568.2009.07042.x)

Amin, E., Wright, N. F., Poirier, G. L., Thomas, K. L., Erichsen, J. T. and Aggleton, J. P. (2010). Selective lamina dysregulation in granular retrosplenial cortex (area 29) after anterior thalamic lesions: an in situ hybridization and trans-neuronal tracing study in rats. Neuroscience, 169 (3), 1255-1267. (10.1016/j.neuroscience.2010.05.055)

Brown, M. W., Warburton, E. C. and Aggleton, J. P. (2010). Recognition memory: Material, processes, and substrates. Hippocampus, 20(11), 1228-1244. (10.1002/hipo.20858)

Horne, M. R., Iordanova, M. D., Albasser, M. M., Aggleton, J. P., Honey, R. C. and Pearce, J. M. (2010). Lesions of the perirhinal cortex do not impair integration of visual and geometric information in rats. Behavioral Neuroscience, 124(3), 311-320. (10.1037/a0019287)

Pothuizen, H. H. J., Davies, M., Aggleton, J. P. and Vann, S. D. (2010). Effects of selective granular retrosplenial cortex lesions on spatial working memory in rats. Behavioural Brain Research, 208(2), 566-575. (10.1016/j.bbr.2010.01.001)

Wright, N. F., Erichsen, J. T., Vann, S. D., O'Mara, S. M. and Aggleton, J. P. (2010). Parallel but separate inputs from limbic cortices to the mammillary bodies and anterior thalamic nuclei in the rat. The Journal of Comparative Neurology, 518(12), 2334-2354. (10.1002/cne.22336)

2009

Aggleton, J. P., Poirier, G. L., Aggleton, H. S., Vann, S. D. and Pearce, J. M. (2009). Lesions of the fornix and anterior thalamic nuclei dissociate different aspects of hippocampal-dependent spatial learning: Implications for the neural basis of scene learning. Behavioral Neuroscience, 123(3), 504-519. (10.1037/a0015404)

Albasser, M. M., Davies, M., Futter, J. E. and Aggleton, J. P. (2009). Magnitude of the object recognition deficit associated with perirhinal cortex damage in rats: Effects of varying the lesion extent and the duration of the sample period. Behavioral Neuroscience, 123(1), 115-124. (10.1037/a0013829)

Denby, C. E., Vann, S. D., Tsivilis, D., Aggleton, J. P., Montaldi, D., Roberts, N. and Mayes, A. R. (2009). The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst. American Journal of Neuroradiology, 30(4), 736-743. (10.3174/ajnr.A1424)

Garden, D. L. F., Massey, P. V., Caruana, D. A., Johnson, B., Warburton, E. C., Aggleton, J. P. and Bashir, Z. I. (2009). Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia. Brain, 132(7), 1847-1857. (10.1093/brain/awp090)

Iordanova, M. D., Burnett, D. J., Aggleton, J. P., Good, M. A. and Honey, R. C. (2009). The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. European Journal of Neuroscience, 30(11), 2177-2189. (10.1111/j.1460-9568.2009.07010.x)

Poirier, G. L. and Aggleton, J. P. (2009). Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity. Neuroscience, 160(2), 452-469. (10.1016/j.neuroscience.2009.02.021)

Pothuizen, H. H. J., Davies, M., Albasser, M. M., Aggleton, J. P. and Vann, S. D. (2009). Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats. European Journal of Neuroscience, 30(5), 877-888. (10.1111/j.1460-9568.2009.06881.x)

Robinson, J., Sanderson, D. J., Aggleton, J. P. and Jenkins, T. A. (2009). Suppression to visual, auditory, and gustatory stimuli habituates normally in rats with excitotoxic lesions of the perirhinal cortex. Behavioral Neuroscience, 123(6), 1238-1250. (10.1037/a0017444)

Vann, S. D., Tsivilis, D., Denby, C. E., Quamme, J. R., Yonelinas, A. P., Aggleton, J. P., Montaldi, D. and Mayes, A. R. (2009). Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods. Proceedings of the National Academy of Sciences, 106(13), 5442-5447. (10.1073/pnas.0812097106)

Vann, S. D., Aggleton, J. P. and Maguire, E. A. (2009). What does the retrosplenial cortex do?. Nature Reviews Neuroscience, 10(11), 792-802. (10.1038/nrn2733)

2008

Aggleton, J. P. (2008). Understanding anterograde amnesia: Disconnections and hidden lesions. Quarterly Journal of Experimental Psychology, 61(10), 1441-1471. (10.1080/17470210802215335)

Aggleton, J. P., Saunders, R. C. and Vann, S. D. (2008). Using hippocampal amnesia to understand the neural basis of diencephalic amnesia. In: Dere, E. et al. eds. Handbook of Episodic Memory, Vol 18. Amsterdam: Elsevier, pp. 503-519. (10.1016/S1569-7339(08)00227-0)

Denby, C., Vann, S. D., Tsivilis, D., Aggleton, J. P., Mayes, A., Sluming, V., Roberts, N. and Montaldi, D. (2008). MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle. Neuroscience Imaging, 2(3), 109-125.

Denby, C., Vann, S. D., Tsivilis, D., Mayes, A., Montaldi, D. and Aggleton, J. P. (2008). Neuroimaging of the fornix: present and future. Neuroscience Imaging, 2(3), 135-148.

Kyd, R. J., Pearce, J. M., Haselgrove, M., Amin, E. and Aggleton, J. P. (2008). The effects of hippocampal system lesions on a novel temporal discrimination task for rats. Behavioural Brain Research, 187(1), 159-171. (10.1016/j.bbr.2007.09.010 )

Poirier, G. L., Shires, K. L., Sugden, D., Amin, E., Thomas, K. L., Carter, D. A. and Aggleton, J. P. (2008). Anterior thalamic lesions produce chronic and profuse transcriptional deregulation in retrosplenial cortex: A model of retrosplenial hypoactivity and covert pathology. Thalamus and Related Systems, 4 (1), 59-77.

Poirier, G. L., Amin, E. and Aggleton, J. P. (2008). Qualitatively different hippocampal subfield engagement emerges with mastery of a spatial memory task by rats. The Journal of Neuroscience, 28(5), 1034-1045. (10.1523/JNEUROSCI.4607-07.2008)

Pothuizen, H. H. J., Aggleton, J. P. and Vann, S. D. (2008). Do rats with retrosplenial cortex lesions lack direction?. European Journal Of Neuroscience, 28(12), 2486-2498. (10.1111/j.1460-9568.2008.06550.x)

Shires, K. L. and Aggleton, J. P. (2008). Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions. European Journal Of Neuroscience, 28(5), 982-996. (10.1111/j.1460-9568.2008.06402.x )

Tsivilis, D., Vann, S. D., Denby, C., Roberts, N., Mayes, A. R., Montaldi, D. and Aggleton, J. P. (2008). A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Nature Neuroscience, 11(7), 834-842. (10.1038/nn.2149)

2007

Aggleton, J. P., Sanderson, D. J. and Pearce, J. M. (2007). Structural learning and the hippocampus. Hippocampus, 17(9), 723-734. (10.1002/hipo.20323)

Albasser, M. M., Poirier, G. L., Warburton, E. C. and Aggleton, J. P. (2007). Hippocampal lesions halve immediate-early gene protein counts in retrosplenial cortex: distal dysfunctions in a spatial memory system. European Journal of Neuroscience, 26(5), 1254-1266. (10.1111/j.1460-9568.2007.05753.x)

Davies, M., Machin, P., Sanderson, D., Pearce, J. M. and Aggleton, J. P. (2007). Neurotoxic lesions of the rat perirhinal and postrhinal cortices and their impact on biconditional visual discrimination tasks. Behavioural Brain Research, 176(2), 274-283. (10.1016/j.bbr.2006.10.005)

Saunders, R. C. and Aggleton, J. P. (2007). Origin and topography of fibers contributing to the fornix in macaque monkeys. Hippocampus, 17(5), 396-411. (10.1002/hipo.20276)

Thapar, A., Harold, G. T., Holmans, P. A., Rice, F., Langley, K., Aggleton, J. P., Fowler, T., Van Den Bree, M. B., Owen, M. J. and O'Donovan, M. C. (2007). Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry, 64(3), 378-379. (10.1001/archpsyc.64.3.378-b)

Vann, S. D., Saunders, R. C. and Aggleton, J. P. (2007). Distinct, parallel pathways link the medial mammillary bodies to the anterior thalamus in macaque monkeys. European Journal of Neuroscience, 26(6), 1575-1586. (10.1111/j.1460-9568.2007.05773.x)

2006

Aggleton, J. P. and Brown, M. W. (2006). Interleaving brain systems for episodic and recognition memory. Trends in Cognitive Sciences, 10(10), 455-463. (10.1016/j.tics.2006.08.003)

Amin, E., Pearce, J. M., Brown, M. W. and Aggleton, J. P. (2006). Novel temporal configurations of stimuli produce discrete changes in immediate-early gene expression in the rat hippocampus. European Journal of Neuroscience, 24(9), 2611-2621. (10.1111/j.1460-9568.2006.05131.x)

Barker, G. R. I., Warburton, E. C., Koder, T., Dolman, N. P., More, J. C. A., Aggleton, J. P., Bashir, Z. I., Auberson, Y. P., Jane, D. E. and Brown, M. W. (2006). The Different Effects on Recognition Memory of Perirhinal Kainate and NMDA Glutamate Receptor Antagonism: Implications for Underlying Plasticity Mechanisms. The Journal of Neuroscience, 26(13), 3561-3566. (10.1523/JNEUROSCI.3154-05.2006)

Futter, J. E. and Aggleton, J. P. (2006). How rats perform spatial working memory tasks: Limitations in the use of egocentric and idiothetic working memory. The Quarterly Journal of Experimental Psychology, 59(1), 77-99. (10.1080/02724990544000068)

Futter, J. E., Davies, M., Bilkey, D. K. and Aggleton, J. P. (2006). The effects of cytotoxic perirhinal cortex lesions on spatial learning by rats: A comparison of the dark Agouti and Sprague-Dawley strains. Behavioral Neuroscience, 120(1), 150-161. (10.1037/0735-7044.120.1.150)

Jenkins, T. A., Amin, E., Brown, M. and Aggleton, J. P. (2006). Changes in immediate early gene expression in the rat brain after unilateral lesions of the hippocampus. Neuroscience, 137(3), 747-759. (10.1016/j.neuroscience.2005.09.034)

Sanderson, D. J., Pearce, J. M., Kyd, R. J. and Aggleton, J. P. (2006). The importance of the rat hippocampus for learning the structure of visual arrays. European Journal of Neuroscience, 24(6), 1781-1788. (10.1111/j.1460-9568.2006.05035.x)

2005

Aggleton, J. P. (2005). Cognitive deficits induced by lesions of structures containing head direction cells. In: Wiener, S. and Taube, J. eds. Head Direction Cells and the Neural Mechanisms Underlying Directional Orientation. Cambridge, MA: MIT Press, pp. 275-296.

Aggleton, J. P. and Brown, M. (2005). Contrasting hippocampal and perirhinalcortex function using immediate early gene imaging. The Quarterly Journal of Experimental Psychology Section B, 58(3-4), 218-233. (10.1080/02724990444000131)

Aggleton, J. P., Vann, S. D. and Saunders, R. C. (2005). Projections from the hippocampal region to the mammillary bodies in macaque monkeys. European Journal of Neuroscience, 22(10), 2519-2530. (10.1111/j.1460-9568.2005.04450.x)

Aggleton, J. P. (2005). Revealing the rat's behavioral repertoire [Book Review]. Nature Neuroscience, 8(7), 843. (10.1038/nn0705-843)

Aggleton, J. P., Vann, S. D., Denby, C., Dix, S., Mayes, A. R., Roberts, N. and Yonelinas, A. P. (2005). Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology. Neuropsychologia, 43(12), 1810-1823. (10.1016/j.neuropsychologia.2005.01.019)

Saunders, R. C., Mishkin, M. and Aggleton, J. P. (2005). Projections from the entorhinal cortex, perirhinal cortex, presubiculum, and parasubiculum to the medial thalamus in macaque monkeys: identifying different pathways using disconnection techniques. Experimental Brain Research, 167(1), 1-16. (10.1007/s00221-005-2361-3)

Thapar, A., Langley, K., Fowler, T., Rice, F., Turic, D., Whittinger, N., Aggleton, J. P., Van Den Bree, M. B., Owen, M. J. and O'Donovan, M. C. (2005). Catechol O-Methyltransferase Gene Variant and Birth Weight Predict Early-Onset Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder. Archives of General Psychiatry, 62(11), 1275-1278. (10.1001/archpsyc.62.11.1275)

Thapar, A., Langley, K., Fowler, T., Rice, F. J., Turic, D., Whittinger, N., Aggleton, J. P., Van den Bree, M. B., Owen, M. J. and O'Donovan, M. C. (2005). Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 62(11), 1275-1278. (10.1001/archpsyc.62.11.1275)

Vann, S. D. and Aggleton, J. P. (2005). Selective Dysgranular Retrosplenial Cortex Lesions in Rats Disrupt Allocentric Performance of the Radial-Arm Maze Task. Behavioral Neuroscience, 119(6), 1682-1686. (10.1037/0735-7044.119.6.1682)

Warburton, E. C., Glover, C. P. J., Massey, P. V., Wan, H., Johnson, B., Bienemann, A., Deuschle, U., Kew, J. N. C., Aggleton, J. P., Bashir, Z. I., Uney, J. and Brown, M. W. (2005). cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory. The Journal of Neuroscience, 25(27), 6296-6303. (10.1523/JNEUROSCI.0506-05.2005)

2004

Aggleton, J. P. and Vann, S. D. (2004). Testing the importance of the retrosplenial navigation system: lesion size but not strain matters: a reply to Harker and Whishaw. Neuroscience & Biobehavioral Reviews, 28(5), 525-531. (10.1016/j.neubiorev.2004.08.003)

Aggleton, J. P., Kyd, R. J. and Bilkey, D. (2004). When is the perirhinal cortex necessary for the performance of spatial memory tasks?. Neuroscience & Biobehavioral Reviews, 28(6), 611-624. (10.1016/j.neubiorev.2004.08.007)

Baird, A. L., Putter, J. E., Muir, J. L. and Aggleton, J. P. (2004). On the Transience of Egocentric Working Memory: Evidence From Testing the Contribution of Limbic Brain Regions. Behavioral Neuroscience, 118(4), 785-797. (10.1037/0735-7044.118.4.785)

Baker, J. R., Bezance, J. B., Zellaby, E. and Aggleton, J. P. (2004). Chewing gum can produce context-dependent effects upon memory. Appetite, 43(2), 207-210. (10.1016/j.appet.2004.06.004)

Fowler, T. A., Thapar, A., Langley, K., Turic, D., Whittinger, N., Van den Bree, M. B., Aggleton, J. P., Owen, M. J. and O'Donovan, M. C. (2004). Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 130B(1), 98-98. (10.1002/ajmg.b.30101)

Jenkins, T. A., Amin, E., Pearce, J. M., Brown, M. W. and Aggleton, J. P. (2004). Novel spatial arrangements of familiar visual stimuli promote activity in the rat hippocampal formation but not the parahippocampal cortices: a c-fos expression study. Neuroscience, 124(1), 43-52. (10.1016/j.neuroscience.2003.11.024)

Jenkins, T. A., Vann, S. D., Amin, E. and Aggleton, J. P. (2004). Anterior thalamic lesions stop immediate early gene activation in selective laminae of the retrosplenial cortex: evidence of covert pathology in rats?. European Journal of Neuroscience, 19(12), 3291-3304. (10.1111/j.0953-816X.2004.03421.x)

Vann, S. D. and Aggleton, J. P. (2004). Testing the importance of the retrosplenial guidance system: effects of different sized retrosplenial cortex lesions on heading direction and spatial working memory. Behavioural Brain Research, 155(1), 97-108. (10.1016/j.bbr.2004.04.005)

Vann, S. D. and Aggleton, J. P. (2004). The mammillary bodies: two memory systems in one?. Nature reviews neuroscience, 5(1), 35-44. (10.1038/nrn1299)

Wan, H., Warburton, E. C., Zhu, X. O., Koder, T. J., Park, Y., Aggleton, J. P., Cho, K., Bashir, Z. I. and Brown, M. W. (2004). Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory. European Journal of Neuroscience, 20(8), 2214-2224. (10.1111/j.1460-9568.2004.03688.x)

2003

Aggleton, J. P., Jenkins, T., Amin, E. and Vann, S. D. (2003). Cortical and limbic interactions in memory processes. European Neuropsychopharmacology, 13(S4), S135-S135. (10.1016/S0924-977X(03)91656-7)

Aggleton, J. P. (2003). The Parahippocampal Region - Emerging From the Shadows?. Cortex, 39(2), 353-355. (10.1016/S0010-9452(08)70116-3)

Barton, R. A., Aggleton, J. P. and Grenyer, R. (2003). Evolutionary coherence of the mammalian amygdala. Proceedings of the Royal Society, Series B: Biological Sciences, 270(1514), 539-543. (10.1098/rspb.2002.2276)

Jenkins, T. A., Amin, E., Harold, G. T., Pearce, J. M. and Aggleton, J. P. (2003). Distinct patterns of hippocampal formation activity associated with different spatial tasks: a Fos imaging study in rats. Experimental Brain Research, 151(4), 514-523. (10.1007/s00221-003-1499-0)

Vann, S. D. and Aggleton, J. P. (2003). Evidence of a spatial encoding deficit in rats with lesions of the mammillary bodies or mammillothalamic tract. Journal of Neuroscience, 23(8), 3506-3514.

Vann, S. D., Honey, R. C. and Aggleton, J. P. (2003). Lesions of the mammillothalamic tract impair the acquisition of spatial but not nonspatial contextual conditional discriminations. European Journal of Neuroscience, 18(8), 2413-2416. (10.1046/j.1460-9568.2003.02959.x)

Vann, S. D., Wilton, L. A. K., Muir, J. L. and Aggleton, J. P. (2003). Testing the importance of the caudal retrosplenial cortex for spatial memory in rats. Behavioural Brain Research, 140(1-2), 107-118. (10.1016/S0166-4328(02)00274-7)

Warburton, E. C., Koder, T., Cho, K., Massey, P. V., Duguid, G., Barker, G. R., Aggleton, J. P., Bashir, Z. I. and Brown, M. W. (2003). Cholinergic transmission is essential for perirhinal cortical plasticity and recognition memory. Neuron, 38(6), 987-996. (10.1016/S0896-6273(03)00358-1)

Zheng, Y., Pearce, J. M., Vann, S. D., Good, M. A., Jenkins, T. A., Smith, P. F. and Aggleton, J. P. (2003). Using Idiothetic Cues to Swim a Path With a Fixed Trajectory and Distance: Necessary Involvement of the Hippocampus, but Not the Retrosplenial Cortex. Behavioral Neuroscience, 117(6), 1363-1377. (10.1037/0735-7044.117.6.1363)

2002

(2002). Episodic memory: new directions in research. Oxford: Oxford University Press.

Aggleton, J. P. and Brown, M. W. (2002). Integrating systems for event memory: Testing the contribution of the fornix. In: Squire, L. and Schacter, D. eds. Neuropsychology of Memory (3rd ed.). New York: Guilford Press, pp. 377-394.

Aggleton, J. P. and Pearce, J. M. (2002). Neural systems underlying episodic memory: insights from animal research. In: Baddeley, A., Aggleton, J. and Conway, M. eds. Episodic Memory: New Directions in Research. Oxford: Oxford University Press, pp. 204-231. (10.1093/acprof:oso/9780198508809.003.0012)

Bussey, T. J. and Aggleton, J. P. (2002). The 'what' and 'where' of event memory: Independence and interactivity within the medial temporal lobe. In: Parker, A., Wilding, E. and Bussey, T. eds. The Cognitive Neuroscience of Memory: Encoding and Retrieval. Hove: Psychology Press, pp. 217-233.

Commins, S., Aggleton, J. P. and O'Mara, S. M. (2002). Physiological evidence for a possible projection from dorsal subiculum to hippocampal area CA1. Experimental Brain Research, 146(2), 155-160. (10.1007/s00221-002-1158-x)

Friedman, D. P., Aggleton, J. P. and Saunders, R. C. (2002). Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the Macaque brain. The Journal of Comparative Neurology, 450(4), 345-365. (10.1002/cne.10336)

Jenkins, T. A., Dias, R., Amin, E. and Aggleton, J. P. (2002). Changes in Fos expression in the rat brain after unilateral lesions of the anterior thalamic nuclei. European Journal of Neuroscience, 16(8), 1425-1432. (10.1046/j.1460-9568.2002.02211.x)

Jenkins, T. A., Dias, R., Amin, E., Brown, M. W. and Aggleton, J. P. (2002). Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. Journal of Neuroscience, 22(12), 5230-5238.

Machin, P., Vann, S. D., Muir, J. L. and Aggleton, J. P. (2002). Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition of performance of tests of allocentric spatial memory. Behavioral Neuroscience, 116(2), 232-240. (10.1037//0735-7044.116.2.232)

Vann, S. D. and Aggleton, J. P. (2002). Extensive cytotoxic lesions of the rat retrosplenial cortex revel consistent deficits on tasks that tax allocentric spatial memory. Behavioral Neuroscience, 116(1), 85-94. (10.1037//0735-7044.116.1.85)

Ward-Robinson, J., Wilton, L. A. K., Muir, J. L., Honey, R. C., Vann, S. D. and Aggleton, J. P. (2002). Sensory preconditioning in rats with lesions of the anterior thalamic nuclei: evidence for intact nonspatial 'relational' processing. Behavioural Brain Research, 133(2), 125-133. (10.1016/S0166-4328(01)00465-X)

2001

Aggleton, J. P. and Pearce, J. M. (2001). Neural systems underlying episodic memory: insights from animal research. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences, 356(1413), 1467-1482. (10.1098/rstb.2001.0946)

Brown, M. W. and Aggleton, J. P. (2001). Recognition memory: what are the roles of the perirhinal cortex and hippocampus?. Nature Reviews Neuroscience, 2(1), 51-61. (10.1038/35049064)

Bussey, T. J., Dias, R., Amin, E., Muir, J. L. and Aggleton, J. P. (2001). Perirhinal cortex and place-object conditional learning in the rat. Behavioral Neuroscience, 115(4), 776-785. (10.1037/0735-7044.115.4.776)

Cho, K., Aggleton, J. P., Brown, M. W. and Bashir, Z. I. (2001). An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat. Journal of Physiology, 532(2), 459-466. (10.1111/j.1469-7793.2001.0459f.x)

Gaffan, E. A., Bannerman, D. M., Warburton, E. C. and Aggleton, J. P. (2001). Rats' processing of visual scenes: effects of lesions to fornix, anterior thalamus, mamillary nuclei or the retrohippocampal region. Behavioural Brain Research, 121(1-2), 103-117. (10.1016/S0166-4328(00)00389-2)

Wan, H., Warburton, E. C., Kusmierek, P., Aggleton, J. P., Kowalska, D. M. and Brown, M. W. (2001). Fos imaging reveals differential neuronal activation of areas of rat temporal cortex by novel and familiar sounds. European Journal of Neuroscience, 14(1), 118-124. (10.1046/j.0953-816x.2001.01625.x)

Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L. and Aggleton, J. P. (2001). The conjoint importance of the hippocampus and anterior thalamic nuclei for allocentric spatial learning: evidence from a disconnection study in the rat. Journal of Neuroscience, 21(18), 7323-7330.

Wilton, L. A. K., Baird, A. L., Muir, J. L. and Aggleton, J. P. (2001). Excitotoxic lesions of the rostral thalamic reticular nucleus do not affect the performance of spatial learning and memory tasks in the rat. Behavioural Brain Research, 120(2), 177-187. (10.1016/S0166-4328(00)00369-7)

Wilton, L. A. K., Baird, A. L., Muir, J. L., Honey, R. C. and Aggleton, J. P. (2001). Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats. Behavioral Neuroscience, 115(4), 861-869. (10.1037/0735-7044.115.4.861)

2000

(2000). The Amygdala: a functional analysis. Oxford: Oxford University Press.

Aggleton, J. P., McMackin, D., Carpenter, K., Hornak, J., Kapur, N., Halpin, S. F., Wiles, C. M., Kamel, H., Brennan, P., Carton, S. and Gaffan, D. (2000). Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix. Brain, 123(4), 800-815. (10.1093/brain/123.4.800)

Aggleton, J. P., Vann, S. D., Oswald, C. J. P. and Good, M. A. (2000). Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer. Hippocampus, 10(4), 466-474. (10.1002/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y)

Aggleton, J. P. and Saunders, J. P. (2000). The amygdala - what's happened in the last decade?. In: Aggleton, J. ed. The Amygdala: A Functional Analysis (2nd ed.). Oxford: Oxford University Press, pp. 1-30.

Aggleton, J. P. and Young, A. W. (2000). The enigma of the amygdala: Concerning its contribution to human emotion. In: Lane, R. and Nadel, L. eds. Cognitive Neuroscience of Emotion. Oxford: Oxford University Press, pp. 106-128.

Banati, R. B., Goerres, G. W., Tjoa, C., Aggleton, J. P. and Grasby, P. (2000). The functional anatomy of visual-tactile integration in man: a study using positron emission tomography. Neuropsychologia, 38(2), 115-124. (10.1016/S0028-3932(99)00074-3)

Barton, R. A. and Aggleton, J. P. (2000). Primate evolution and the amygdala. In: Aggleton, J. ed. The Amygdala: A Functional Analysis (2nd ed.). Oxford: Oxford University Press, pp. 479-508.

Bussey, T. J., Duck, J., Muir, J. L. and Aggleton, J. P. (2000). Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat. Behavioural Brain Research, 111(1-2), 187-202. (10.1016/S0166-4328(00)00155-8)

Bussey, T. J., Dias, R., Redhead, E. S., Pearce, J. M., Muir, J. L. and Aggleton, J. P. (2000). Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions. Experimental Brain Research, 134(4), 506-519. (10.1007/s002210000481)

Cho, K., Kemp, N., Noel, J., Aggleton, J. P., Brown, M. W. and Bashir, Z. I. (2000). A new form of long-term depression in the perirhinal cortex. Nature Neuroscience, 3(2), 150-156. (10.1038/72093)

Dias, R. and Aggleton, J. P. (2000). Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioural flexibility. European Journal of Neuroscience, 12(12), 4457-4466. (10.1046/j.0953-816X.2000.01323.x)

Holdstock, J. S., Mayes, A. R., Cezayirli, E., Isaac, C. L., Aggleton, J. P. and Roberts, N. (2000). A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage. Neuropsychologia, 38(4), 410-425. (10.1016/S0028-3932(99)00099-8)

Vann, S. D., Brown, M. W. and Aggleton, J. P. (2000). Fos expression in the rostral thalamic nuclei and associated cortical regions in response to different spatial memory tests. Neuroscience, 101(4), 983-991. (10.1016/S0306-4522(00)00288-8)

Vann, S. D., Brown, M. W., Erichsen, J. T. and Aggleton, J. P. (2000). Fos imaging reveals differential patterns of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests. Journal of Neuroscience, 20(7), 2711-2718.

Vann, S. D., Brown, M. W., Erichsen, J. T. and Aggleton, J. P. (2000). Using Fos imaging in the rat to reveal the anatomical extent of the disruptive effects of fornix lesions. Journal of Neuroscience, 20(21), 8144-8152.

Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L. and Aggleton, J. P. (2000). Disconnecting hippocampal projections to the anterior thalamus produces deficits on tests of spatial memory in rats. European Journal of Neuroscience, 12(5), 1714-1726. (10.1046/j.1460-9568.2000.00039.x)

1999

Aggleton, J. (1999). Mapping recognition memory in the primate brain: why it's sometimes right to be wrong. Brain Research Bulletin, 50(5-6), 447-448. (10.1016/S0361-9230(99)00127-6 )

Aggleton, J. P. and Brown, M. W. (1999). Episodic memory, amnesia and the hippocampal - anterior thalamic axis. Behavioral and Brain Sciences, 22(3), 425-444.

Aggleton, J. P. and Brown, M. W. (1999). Thanks for the memories: Extending the hippocampal-diencephalic mnemonic system [Letter]. Behavioral and Brain Sciences, 22(3), 471-479. (10.1017/S0140525X99482032)

Aggleton, J. P. and Waskett, L. (1999). The ability of odours to serve as state-dependent cues for real-world memories: Can Viking smells aid the recall of Viking experiences?. British Journal of Psychology, 90(1), 1-7. (10.1348/000712699161170)

Bussey, T. J., Muir, J. L. and Aggleton, J. P. (1999). Functionally dissociating aspects of event memory: The effects of combined perirhinal and postrhinal lesions on object and place memory in the rat. The Journal of Neuroscience, 19(1), 495-502.

Dix, S. L. and Aggleton, J. (1999). Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behavioural Brain Research, 99(2), 191-200. (10.1016/S0166-4328(98)00079-5)

Holdstock, J. S., Mayes, A., Cezayirli, E., Aggleton, J. and Roberts, N. (1999). A comparison of egocentric and allocentric spatial memory in medial temporal lobe and Korsakoff amnesics. Cortex, 35(4), 479-501. (10.1016/S0010-9452(08)70814-1)

McCaffery, B., Cho, K., Bortolotto, Z. A., Aggleton, J., Brown, M. W., Conquet, F., Collingridge, G. L. and Bashir, Z. I. (1999). Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro. Neuroscience, 93(3), 977-984. (10.1016/S0306-4522(99)00205-5)

Wan, H., Aggleton, J. P. and Brown, M. W. (1999). Different contributions of the hippocampus and perirhinal cortex to recognition memory. The Journal of Neuroscience, 19(3), 1142-1148.

Warburton, E. C., Morgan, A., Baird, A. L., Muir, J. L. and Aggleton, J. P. (1999). Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats?. Behavioral Neuroscience, 113(5), 956. (10.1037//0735-7044.113.5.956)

1998

Bussey, T. J., Warburton, E. C., Aggleton, J. P. and Muir, J. L. (1998). Fornix Lesions Can Facilitate Acquisition of the Transverse Patterning Task: A Challenge for "Configural" Theories of Hippocampal Function. The Journal of Neuroscience, 18(4), 1622-1631.

Hunt, P. R. and Aggleton, J. P. (1998). Neurotoxic lesions of the dorsomedial thalamus impair the acquisition but not the performance of delayed matching to place by rats: a deficit in shifting response rules. The Journal of Neuroscience, 18(23), 10045-10052.

Hunt, P. R. and Aggleton, J. (1998). An examination of the spatial working memory deficit following neurotoxic medial dorsal thalamic lesions in rats. Behavioural Brain Research, 97(1-2), 129-141. (10.1016/S0166-4328(98)00033-3)

Reeve, D. K. and Aggleton, J. P. (1998). On the specificity of expert knowledge about a soap opera: an everyday story of farming folk. Applied Cognitive Psychology, 12(1), 35-42. (10.1002/%28SICI%291099-0720%28199802%2912:1%3C35::AID-ACP485%3E3.0.CO;2-2)

Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A. and Aggleton, J. (1998). Recognition memory in rats-I. Concepts and classification. Progress in Neurobiology, 54(3), 289-311. (10.1016/S0301-0082(97)00060-9)

Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A. and Aggleton, J. (1998). Recognition memory in rats-II. Neuroanatomical substrates. Progress in Neurobiology, 54(3), 313-332. (10.1016/S0301-0082(97)00061-0)

Steckler, T., Sahgal, A., Aggleton, J. and Drinkenburg, W. H. I. M. (1998). Recognition memory in rats-III. Neurochemical substrates. Progress in Neurobiology, 54(3), 333-348. (10.1016/S0301-0082(97)00062-2)

Warburton, E. C., Aggleton, J. P. and Muir, J. L. (1998). Comparing the effects of selective cingulate cortex and cingulum bundle lesions on a spatial navigation task. European Journal of Neuroscience, 10(2), 622-634. (10.1046/j.1460-9568.1998.00074.x)

Warburton, E. and Aggleton, J. (1998). Differential deficits in the Morris water maze following cytotoxic lesions of the anterior thalamus and fornix transection. Behavioural Brain Research, 98(1), 27-38. (10.1016/S0166-4328(98)00047-3)

1997

Aggleton, J., Keen, S., Warburton, E. C. and Bussey, T. J. (1997). Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Research Bulletin, 43(3), 279-287. (10.1016/S0361-9230(97)00007-5)

Aggleton, J. P. and Saunders, R. C. (1997). The Relationships Between Temporal Lobe and Diencephalic Structures Implicated in Anterograde Amnesia. Memory, 5(1-2), 49-72. (10.1080/741941143)

Bentivoglio, M., Aggleton, J. P. and Mishkin, M. (1997). The thalamus and memory formation. In: Steriade, M., Jones, E. and McCormick, D. eds. Thalamus. Amsterdam: Elsevier, pp. 689-720.

Ennaceur, A., Aggleton, J. P. and Fray, P. J. (1997). Delayed non-matching to sample in a novel automated visual apparatus using mixed retention intervals. Neuroscience Research Communications, 20(2), 103-111. (10.1002/%28SICI%291520-6769%28199703%2920:2%3C103::AID-NRC191%3E3.0.CO;2-A)

Ennaceur, A., Neave, N. and Aggleton, J. P. (1997). Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Experimental Brain Research, 113(3), 509-519. (10.1007/PL00005603)

Ennaceur, A. and Aggleton, J. (1997). The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behavioural Brain Research, 88(2), 181-193. (10.1016/S0166-4328(97)02297-3)

Good, J. M. M., Aggleton, J. P., Kentridge, R. W., Barker, J. G. M. and Neave, N. J. (1997). Measuring Musical Aptitude in Children: On the Role of Age, Handedness, Scholastic Achievement, and Socioeconomic Status. Psychology of Music, 25(1), 57-69. (10.1177/0305735697251005)

Neave, N., Nagle, S. and Aggleton, J. P. (1997). Evidence for the Involvement of the Mammillary Bodies and Cingulum Bundle in Allocentric Spatial Processing by Rats. European Journal of Neuroscience, 9(5), 941-955. (10.1111/j.1460-9568.1997.tb01445.x)

Scott, S. K., Young, A. W., Calder, A. J., Hellawell, D. J., Aggleton, J. P. and Johnsons, M. (1997). Impaired auditory recognition of fear and anger following bilateral amygdala lesions [Letter]. Nature, 385(6613), 254-257. (10.1038/385254a0)

Warburton, E. C., Baird, A. and Aggleton, J. (1997). Assessing the magnitude of the allocentric spatial deficit associated with complete loss of the anterior thalamic nuclei in rats. Behavioural Brain Research, 87(2), 223-232. (10.1016/S0166-4328(97)02285-7)

Young, A. W. and Aggleton, J. P. (1997). Response from Young and Aggleton [reply to Daniel Tranel: Emotional processing and the human amygdala]. Trends in Cognitive Sciences, 1(2), 47-48. (10.1016/S1364-6613(97)01020-6)

Zhu, X. O., McCabe, B. J., Aggleton, J. P. and Brown, M. W. (1997). Differential activation of the rat hippocampus and perirhinal cortex by novel visual stimuli and a novel environment. Neuroscience Letters, 229(2), 141-143. (10.1016/S0304-3940(97)00437-0)

1996

Aggleton, J. P. and Shaw, C. (1996). Amnesia and recognition memory: a re-analysis of psychometric data. Neuropsychologia, 34(1), 51-62. (10.1016/0028-3932(95)00150-6)

Aggleton, J. P. (1996). The ability of different strains of rats to acquire a visual nonmatching-to-sample task. Psychobiology, 24, 44-48.

Aggleton, J. P., Hunt, P. R., Nagle, S. and Neave, N. (1996). The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat. Behavioural Brain Research, 80(1-2), 75-85. (10.1016/0166-4328(96)00022-8)

Ennaceur, A., Neave, N. and Aggleton, J. P. (1996). Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat. Behavioural Brain Research, 80(1-2), 9-25. (10.1016/0166-4328(96)00006-X)

Neave, N., Nagle, S., Sahgal, A. and Aggleton, J. P. (1996). The effects of discrete cingulum bundle lesions in the rat on the acquisition and performance of two tests of spatial working memory. Behavioural Brain Research, 80(1-2), 75-85. (10.1016/0166-4328(96)00022-8)

Zhu, X. O., McCabe, B. J., Aggleton, J. P. and Brown, M. W. (1996). Mapping visual recognition memory through expression of the immediate early gene c-fos. NeuroReport, 7(11), 1871-1875.

1995

Aggleton, J. P., Neave, N., Nagle, S. and Hunt, P. R. (1995). A comparison of the effects of anterior thalamic, mamillary body and fornix lesions on reinforced spatial alternation. Behavioural Brain Research, 68(1), 91-101. (10.1016/0166-4328(94)00163-A)

Aggleton, J. P., Neave, N., Nagle, S. and Sahgal, A. (1995). A comparison of the effects of medial prefrontal, cingulate cortex, and cingulum bundle lesions on tests of spatial memory: evidence of a double dissociation between frontal and cingulum bundle contributions. The Journal of Neuroscience, 15(11), 7270-7281.

Holdstock, J., Shaw, C. and Aggleton, J. P. (1995). The performance of amnesic subjects on tests of delayed matching-to-sample and delayed matching-to-position. Neuropsychologia, 33(12), 1583-1596. (10.1016/0028-3932(95)00145-X)

Shaw, C. and Aggleton, J. P. (1995). Evidence for the independence of recognition and recency memory in amnesic subjects. Cortex, 31(1), 57-71.

Young, A. W., Aggleton, J. P., Hellawell, D. J., Johnson, M., Broks, P. and Hanley, J. R. (1995). Face processing impairments after amygdalotomy. Brain, 118(1), 15-24. (10.1093/brain/118.1.15)

Zhu, X. O., Brown, M. W., McCabe, B. J. and Aggleton, J. P. (1995). Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain. Neuroscience, 69(3), 821-829. (10.1016/0306-4522(95)00320-I)

Zhu, X. O., Brown, M. W. and Aggleton, J. P. (1995). Neuronal Signalling of Information Important to Visual Recognition-Memory in Rat Rhinal aid Neighbouring Cortices. European Journal of Neuroscience, 7(4), 753-765. (10.1111/j.1460-9568.1995.tb00679.x)

1994

Hunt, P., Neave, N., Shaw, C. and Aggleton, J. P. (1994). The effects of lesions to the fornix and dorsomedial thalamus on concurrent discrimination learning by rats. Behavioural Brain Research, 62(2), 195-205. (10.1016/0166-4328(94)90028-0)

Neave, N., Lloyd, S., Sahgal, A. and Aggleton, J. (1994). Lack of effect of lesions in the anterior cingulate cortex and retrosplenial cortex on certain tests of spatial memory in the rat. Behavioural Brain Research, 65(1), 89-101. (10.1016/0166-4328(94)90077-9)

Shaw, C. and Aggleton, J. P. (1994). The ability of amnesic subjects to estimate time intervals. Neuropsychologia, 32(7), 857-873. (10.1016/0028-3932(94)90023-X)

1993

Aggleton, J. P. and Sahgal, A. (1993). The contribution of the anterior thalamic nuclei to anterograde amnesia. Neuropsychologia, 31(10), 1001-1019. (10.1016/0028-3932(93)90029-Y)

Neave, N., Sahgal, A. and Aggleton, J. P. (1993). Lack of effect of dorsomedial thalamic lesions on automated tests of spatial memory in the rat. Behavioural Brain Research, 55(1), 39-49. (10.1016/0166-4328(93)90005-B)

Shaw, C. and Aggleton, J. P. (1993). The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats. Behavioural Brain Research, 54(1), 91-102. (10.1016/0166-4328(93)90051-Q)

1991

Hunt, P. and Aggleton, J. P. (1991). Medial dorsal thalamic lesions and working memory in the rat. Behavioral and Neural Biology, 55(2), 227-246. (10.1016/0163-1047(91)80141-Z)

1990

Aggleton, J. P. and Mishkin, M. (1990). Visual impairments in macaques following inferior temporal lesions are exacerbated selectively by additional damage to superior temporal sulcus. Behavioural Brain Research, 39(3), 262-274. (10.1016/0166-4328(90)90032-A)

Shaw, C., Kentridge, R. W. and Aggleton, J. P. (1990). Cross-modal matching by amnesic subjects. Neuropsychologia, 28(7), 665-671. (10.1016/0028-3932(90)90121-4)

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Research

Research Topics and Related Papers

My research examines how different brain regions interact to support different forms of memory. The focus of this research has largely been on two distinct regions within the brain, the medial temporal lobe and the medial diencephalon. These questions are being pursued at a variety of levels; anatomical, behavioural and clinical. My anatomical studies examine the nature of the interactions between the temporal lobe and medial diencephalic structures, i.e. their origin, the routes taken within the brain, and the degree to which single pathways link multiple regions (see below).

Fig. 1. Picture of the rat subiculum within the hippocampal formation showing the separate, but adjacent, populations of nerve cells that project to the mammillary bodies (green) and anterior thalamus (red) (Wright et al., Journal of Comparative Neurology, in press).

My behavioural studies examine animal models of amnesic conditions. For this reason I am very interested in refining learning tasks that tax the specific classes of cognitive problems found in amnesia. An important component has been the development of new tests of recognition memory, so enabling the study of the neural basis of recognition memory. I have proposed new models of how recognition memory and recall interact, and then tested these models with rodents and with clinical populations. My rodent studies seek to understand how the perirhinal cortex contributes to recognition and other forms of memory using a combination of lesion and gene imaging techniques. This research is in close collaboration with researchers at Bristol University, and is funded by a Wellcome Trust Programme Grant. At the same time, I am trying to tease apart the functional contributions of a series of parallel temporal – medial diencephalic pathways that conjointly support memory (Fig. 2).

Fig. 2. Schematic drawing of pathways running between the medial temporal lobe and the medial diencephalon that potentially support memory.

A further part of my research involves clinical studies of amnesia. An example of the latter was a survey of patients across the UK who received surgery to remove a colloid cyst in the third ventricle. We calculated the extent to which these patients suffer medial diencephalic damage and were directly able to relate these changes to their loss of episodic memory (Fig. 3). The results provided unusually strong evidence concerning, 1) the anatomical basis of diencephalic amnesia, 2) the relationship between mechanisms for recall and for recognition in the brain.

Fig. 3. Left: MRI analyses of colloid cyst patients. Right: positive correlation between mammillary body volume and memory (recall). (From Tsivilis et al., Nature Neuroscience, 2008)

Funding

2009: Royal Society Wolfson Research Merit Award, 2009-2014, £75,000

2009: International Investment Opportunities Fund New Zealand. ‘Rescuing memory loss after brain injury’. P.I. John C. Dalrymple-Alford. 3 years $380,000 NZ

2009: Wellcome Trust ‘Interleaving brain systems for recognition and episodic memory’. JPA Lead Applicant - with John Pearce, Malcolm Brown, Zafir Bashir, Clea Warburton, £1,569,168 for 5 years

2007: Wellcome Trust PhD Programme in Integrative Neuroscience 2008-2013– Lead Applicant and Deputy Directory. £4,000,000 over 6 years.

2006: Wellcome Trust. Why are there parallel hippocampal – diencephalic pathways for event memory? Lead applicant. £158,395 for 3 years.

2006: Wellcome Trust. Why are there parallel hippocampal – diencephalic pathways for event memory? Co-applicant with Erichsen, Vann, O’Mara. €203,428, for 3 years

Research Group

Current researchers based in Cardiff University include: Dr Mathieu Albasser, Dr Nick Wright, Ms Eman Amin, and Ms Julie Dumont.

Research Collaborators

UK based Professor Malcolm Brown, Bristol University Professory Zafir Bashir, Bristol University Dr Clea Warburton, Bristol University Dr Seralynne Vann, Cardiff University

International Dr Richard Saunders, NIMH, NIH Dr Mort Mishkin, NIMH, NIH Professor John Dalrymple-Alford, Christchurch, New Zealand Professor Shane O’Mara, Trinity College, Dublin

Postgraduate Students

Postgraduate Research Interests

There are currently two different, but related, programmes of research.

The first programme concerns temporal lobe structures and how they interact to support different forms of recognition memory. The principal area of interest concerns the behavioural analysis of recognition memory and other closely related forms of memory. Structural interactions are examined with a mixture of lesion, gene-expression and anatomical studies.

The second programme concerns the functions of structures in the diencephalon (thalamus and hypothalamus), and how these structures support memory. Here the focus is more on aspects of spatial memory. As part of this research, the significance of the links between the temporal lobe and diencephalon are also of especial interest.

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application here.

Current Students

Ms Julie Dumont

Previous Students

R. Kentridge "Dopamine and the Perception of Reward" Ph.D Durham University, 1988. Currently - Reader, Department of Psychology, Durham University.

C. Shaw "The Neural Basis of Associative Memory: An Examination of Cross-Species

Comparisons" Ph.D Durham University, 1992. Currently - University Secretary and Director of Corporate Services and Human Resources (Cardiff University).

N. Neave “Thalamo-cortical contributions to spatial working memory in the rat” Ph.D Durham University, 1996. Currently - Senior Lecturer, Department of Psychology, University of Northumbria.

P. Hunt “ An examination of the effects of thalamic lesions on learning and memory in rats” Ph.D. Open University, 1999. Currently - Biological Standards Officer, Cardiff University.

S. Dix “Using dual-process theories to re-examine the neural substrates of recollective and familiarity processes in recognition” Ph.D Cardiff University 2000. Currently - Senior Scientist, Neurodegeneration Drug Hunting Team, Eli Lilley.

S. D. Vann “Neural systems underlying spatial memory” Ph.D Cardiff University, 2000. Currently a BBSRC (David Phillips) Research Fellow

D. Sanderson “The hippocampus and structural learning” Ph.D. Cardiff University, 2005. Currently - Research Associate, Dept. Experimental Psychology, University of Oxford.

K. Shires “Using IEGs to uncover pathways for spatial learning in the rat.” Ph. D. Cardiff University, 2006 Currently - Research Associate, Neuroscience Department, Edinburgh University

G. Poirier “Sensitivity of the retrosplenial cortex to distal damage in a network associated with spatial memory.” Ph.D. Cardiff University. 2007 Post-doctoral research scientist, École Polytechnique Fédérale de Lausanne, Brain Mind Institute, Laboratory of Behavioral Genetics

M. Albasser "The use of immediate-early gene expression to map the relationships between limbic structures supporting memory" Ph.D. Cardiff University, 2009. Currently Research Associate School of Psychology, Cardiff University, 2010.

Biography

Undergraduate Education

1965-72: Trinity School, Croydon 1973-6: B.A. University of Cambridge, Clare College; Natural Sciences

Postgraduate Education

1980: D.Phil., Jesus College, University of Oxford, Thesis: Anatomical and Functional Subdivisions of the Amygdala. Supervisor: Dr. R.E. Passingham

Awards/External Committees

Awards

2002: Fellow of the Academy of Medical Sciences (FMedSci) 2004-6: President of the European Brain and Behaviour Society 2006: Experimental Psychology Society – 4th Mid Career Award Prize 2007-9: Council Member, Academy of Medical Sciences 2009-2014: Royal Society Wolfson Research Merit Award

External Committees

Editorial Boards 1997-2000: European Journal of Neuroscience - Receiving Editor 1990-1993: Quarterly Journal of Experimental Psychology - Section B Associate Editor 1995-present: Brain Research Bulletin - Editorial Advisory Board 1995-present: Neuroscience and Biobehavioral Reviews - Editorial Advisory Board 1998-present: Behavioural Brain Research - Editorial Board 1998-present: Behavioral Neuroscience - Editorial Board 2000-present: European Journal of Neuroscience – Editorial Board 2001-present: Neuropsychologia –Board of Associate Editors

National Committees 1993-1995: MRC - NAHH (Neuroscience Approach to Human Health) Steering Committee 1996-2002: MRC - Neurosciences and Mental Health Studentships Allocation Panel 1997: MRC - Clinical Training and Career Development Panel 1997-2001: MRC - Neurosciences and Mental Health Board 1997-2002: MRC - Clinical Trials - Clinical Cross-Board subgroup 2003-2004: MRC – Cross Board 2008-present: MRC ad hoc committees

2004-2007: Wellcome Trust - Cognitive and Higher Systems Funding Committee 2004-2007: Wellcome Trust - Neuroscience and Mental Health (Joint) Committee 2007-present: Wellcome Trust - Chair of Cognitive and Higher Systems Funding Committee 2007-present: Wellcome Trust - Co Chair Neuroscience and Mental Health (Joint) Committee 2008-present: Wellcome Trust - Strategy Committee for Neuroscience and Mental Health 2009-present: British Neuroscience Association - Scientific Strategy Board

International Committees 2004-2006: President of the European Brain and Behaviour Society 2002-2004: Council member of the European Brain and Behaviour Society 2004-2006: Council member of FENS (Federation of European Neuroscience Societies) 2008: Programme committee member for FENS (Geneva) 2007: International Jury for Inaugural Evens Scientific Research Challenge

Employment

1994-present: Professor of Cognitive Neuroscience, School of Psychology, University of Wales, Cardiff 1992-1994: Senior Lecturer, Department of Psychology, University of Durham 1983–1992: Lecturer, Department of Psychology, University of Durham 1980-1983: NIH Visiting Fellow, National Institute of Mental Health, Bethesda, Maryland. Laboratory of Neuropsychology (Head: Dr. M. Mishkin)

School of Psychology

Professor John P Aggleton - BA MA Cantab, DPhil Oxon

Overview

Research Summary

Teaching Summary

Selected Publications (2008 onwards)

2013

2012

2011

2010

2009

2008

Publications

Online Publications

Full List of Publications

Forthcoming

2013

2012

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Research

Research Topics and Related Papers

Funding

Research Group

Research Collaborators

Postgraduate Students

Postgraduate Research Interests

Current Students

Previous Students

Biography

Undergraduate Education

Postgraduate Education

Awards/External Committees

Employment