The BGG works on one of the biggest questions in biology today. How do the genetic cards we are dealt at the moment of conception interact with our lifetime experiences, from womb to grave, to give rise to our unique behavioural profile and our risk of neuropsychiatric disorder? Until recently, the complexities of such gene-environment interactions seemed overwhelming but new methods and insights now mean this problem is becoming increasingly tractable.
Active areas of research in the BGG include:
- Epigenetic regulation of behaviour and its role in mediating life events
- Genomic imprinting in the brain
- X-linked mechanisms influencing the genetic basis of sexually dimorphic behaviour
- Models of the genetic risk factors in schizophrenia
- Familial dementias and risk of neuropsychiatric illness
We work with colleagues in Cardiff, the UK and Internationally, to develop our work and to translate our basic research findings into clinically relevant areas.
News and Announcements
Congratulations to Anna Powell and Jessica Eddy who successfully defended their theses!
Dent, Isles & Humby. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience (in press)
Kopsida et al (2013) Dissociable Effects of Sry and Sex Chromosome Complement on Activity, Feeding and Anxiety-Related Behaviours in Mice PLOS ONE 8(8):e73699 [link]
Dent & Isles (2013) Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10. Mammalian Genome (in press) [link]